Tuncay Gorkem, Karaer Abdullah, İnci Coşkun Ebru, Baloğlu Demet, Tecellioğlu Ayşe Nihan
Division of Reproductive Endocrinology and Infertility, Departments of Obstetrics and Gynecology, School of Medicine, Inonu University, 44315, Malatya, Turkey.
Departments of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey.
BMC Womens Health. 2018 Mar 20;18(1):51. doi: 10.1186/s12905-018-0541-0.
The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women.
A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38-2.49 mIU/Land 2.50-4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L).
There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79-3.53), 1.08 (95% CI: 0.09-13.1), and 1.79 (95% CI: 0.77-4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit-administration rate) between the two groups.
Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.
This study is retrospectively registered by Ethical Review Board at Inonu University in 19th December 2017; Ethics approval no is 2017-27-20.
本研究旨在探讨促甲状腺激素（TSH）水平对甲状腺功能正常女性宫内人工授精（IUI）结局的影响。
进行一项回顾性队列研究。本研究纳入了在我们生殖中心开始首个IUI周期的302名女性。根据孕前TSH值将患者分为两组：0.38 - 2.49 mIU/L和2.50 - 4.99 mIU/L。临床妊娠率是主要结局参数。作为次要参数，我们根据孕前TSH阈值（<2.5和<5.00 mIU/L）评估自然流产率、活产分娩率和围产期结局的差异。
两组在临床妊娠、流产和活产率方面无显著差异，优势比分别为1.67（95%CI：0.79 - 3.53）、1.08（95%CI：0.09 - 13.1）和1.79（95%CI：0.77 - 4.2）。此外，两组在围产期结局（分娩孕周、出生体重和新生儿重症监护病房入住率）方面也无显著差异。
我们的研究结果表明，在甲状腺功能正常的患者中，孕前TSH值处于高正常范围（2.5至4.9 mIU/L之间）对IUI结局没有负面影响。
本研究于2017年12月19日由伊诺努大学伦理审查委员会进行回顾性注册；伦理批准号为2017 - 27 - 20。
