Dishevelled：复杂 Wnt 信号的杰出传导者。
Dishevelled: A masterful conductor of complex Wnt signals.
机构信息
Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Department of Biomedical Sciences, University of Minnesota, School of Medicine, Duluth, MN, USA.
出版信息
Cell Signal. 2018 Jul;47:52-64. doi: 10.1016/j.cellsig.2018.03.004. Epub 2018 Mar 17.
Abstract
The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity [1-3]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates respectively) gained popularity when it was discovered that it plays a key role in segment polarity during early embryonic development in Drosophila [4]. Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5-10]. Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. This review will revisit seminal discoveries and also summarize recent advances in characterizing the role of Dishevelled in both normal and pathophysiological settings.
摘要
Dishevelled 基因最初是在具有定向毛发和刚毛极性紊乱的果蝇突变体中被鉴定出来的[1-3]。当发现 Dsh 基因（果蝇中的 Dsh/Dvl 和脊椎动物中的 Dvl）在果蝇早期胚胎发育中在节极性中发挥关键作用时，它变得非常流行[4]。随后，在爪蟾（Xdsh）、小鼠（Dvl1、Dvl2、Dvl3）和人类（DVL1、DVL2、DVL3）中鉴定出了 Dishevelled 基因的脊椎动物同源物[5-10]。Dishevelled 作为 Wnt 信号通路的主要组成部分发挥作用，调控包括细胞增殖、存活、迁移、分化、极性和干细胞更新在内的多种细胞过程。这篇综述将重新审视开创性的发现，并总结最近在描述 Dishevelled 在正常和病理生理环境中的作用方面的进展。
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