Teng Dongling, Wu Keyan, Sun Yunyun, Zhang Min, Wang Dan, Wu Jian, Yin Tao, Gong Weijuan, Ding Yanbing, Xiao Weiming, Lu Guotao, Li Weiqin
Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, Jiangsu, China.
Laboratory of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, Jiangsu, China.
Oncotarget. 2018 Jan 4;9(16):12745-12753. doi: 10.18632/oncotarget.23993. eCollection 2018 Feb 27.
Carbohydrate antigen 19-9 (CA199) has been identified as a tumor marker for pancreatic cancer but also increases in benign lesions of the digestive system. However, literature associated with the relationship between CA199 and acute pancreatitis (AP) is limited. This study aimed to focus on serum CA199 level measurements in AP patients and the associated clinical significance.
From January 2006 to December 2015, 1,609 consecutive patients with AP were admitted to our department and included in the study. The relationships among the etiology of AP, the disease severity, the incidence of pancreatic cancer during hospitalization and CA199 levels were analyzed.
Serum CA199 levels were measured for 693 of 1,609 AP patients. Of those patients, 186 (26.8%) had elevated CA199 levels (> 37 U/ml). Patients with high CA199 levels were older and had predominantly biliary causes in comparison with patients with normal CA199 levels. There were no definite specific correlations between CA199 levels and disease severity in AP. In addition, serum levels of CA199 positively correlated with serum alanine aminotransferase, aspartate transaminase, glutamyl transpeptidase, alkaline phosphatase and creatinine levels. After stratification, the incidence of pancreatic cancer increased proportionally to CA199 levels in AP patients.
Serum CA199 levels was elevated in patients with AP, especially in patients with biliary pancreatitis. AP patients with significantly increased CA199 levels may have a higher risk for the presence of pancreatic cancer. We recommended routinely monitoring CA199 levels during hospitalization for AP patients.
糖类抗原19-9（CA199）已被确定为胰腺癌的肿瘤标志物，但在消化系统良性病变中也会升高。然而，关于CA199与急性胰腺炎（AP）之间关系的文献有限。本研究旨在关注AP患者血清CA199水平的测定及其相关临床意义。
2006年1月至2015年12月，1609例连续的AP患者入住我科并纳入研究。分析了AP的病因、疾病严重程度、住院期间胰腺癌的发生率与CA199水平之间的关系。
对1609例AP患者中的693例进行了血清CA199水平测定。其中，186例（26.8%）CA199水平升高（>37 U/ml）。与CA199水平正常的患者相比，CA199水平高的患者年龄较大，且主要病因是胆源性。AP中CA199水平与疾病严重程度之间没有明确的特定相关性。此外，血清CA199水平与血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、谷氨酰转肽酶、碱性磷酸酶和肌酐水平呈正相关。分层后，AP患者中胰腺癌的发生率与CA199水平成比例增加。
AP患者血清CA199水平升高，尤其是胆源性胰腺炎患者。CA199水平显著升高的AP患者患胰腺癌的风险可能更高。我们建议对AP患者住院期间常规监测CA199水平。
