Al Hashan Ghadi Mohammed, Abo El-Fetoh Nagah Mohamed, Nasser Iman Ali, Alyami Atheer Raja, Almagbool Albatool Saleh Hassan, Hatuwh Taghreed Ahmad Eidih, Alyami Fatimah Hamad Saleh, Al Yami Maram Hamad, Alqahtani Manar Hamad, Almardhamah Nouf Mubarak Ali, Alanazi Tahani Mohammed, Ali Wafaa Mohamed Bakr, Halzaa Ahad Mesfer, Alshehri Ayah Abdullah
Medical Intern, Najran University, Najran, Kingdom of Saudi Arabia.
Associate Professor, Family and Community Medicine Department, Faculty of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia.
Electron Physician. 2017 Dec 25;9(12):5902-5907. doi: 10.19082/5902. eCollection 2017 Dec.
With more than 500,000 new cases annually, human brucellosis is the commonest zoonotic disease worldwide. In some endemic countries, its prevalence is more than 10 per 100,000 population.
The aim of this study was to determine the magnitude of the problem and the clinical features, laboratory findings, treatment given and complications seen in children with brucellosis in Najran City, Kingdom of Saudi Arabia.
This is a case-series study by analysis of data of children known or diagnosed to have brucellosis for the last 4 years in Najran City. Data was obtained by reviewing the hospital records of the Maternity and Children Hospital and Najran Armed Forces Hospital in Najran during the period from 2013 to 2017. The statistical analysis was carried out using SPSS version 16.0. Since it was the first report of brucellosis on the study population, we used descriptive statistics (frequency, proportion, mean, and standard deviation) for presenting the findings.
We studied 57 diagnosed cases of child brucellosis throughout the past 4 years in Najran, south Saudi Arabia with an average number of about 12 cases per year. Of the cases, 15.8% reported a history of ingestion of raw milk and dairy product and only 1.8% of them reported a history of animal contact while 82.4% confirmed unknown mode of transmission. Fever was the only finding in 36.8%, fever and arthralgia 21.1%, and fever and myalgia 19.3%. Two thirds of the cases were diagnosed by standard agglutination test (SAT). Hepatosplenomegaly was found in 10.5%. Rifampicin was the antibiotic of choice and 70.2% of cases have been cured but 3.5% relapsed and 1.8% died from complications.
Results suggest brucellosis be considered in every child living in an endemic area, showing symptoms of fever and having a history of ingestion of raw milk and dairy product and/or animal contact.Prevention should rely on health education of the public about different issues of the disease including boiling raw milk.
人类布鲁氏菌病每年新增病例超过50万例，是全球最常见的人畜共患病。在一些流行国家，其患病率超过十万分之十。
本研究旨在确定沙特阿拉伯王国纳季兰市儿童布鲁氏菌病问题的严重程度、临床特征、实验室检查结果、治疗情况及并发症。
这是一项病例系列研究，通过分析纳季兰市过去4年已知或诊断为布鲁氏菌病的儿童数据进行。数据通过回顾2013年至2017年期间纳季兰市妇幼医院和纳季兰武装部队医院的病历获得。使用SPSS 16.0版进行统计分析。由于这是关于该研究人群布鲁氏菌病的首次报告，我们使用描述性统计（频率、比例、均值和标准差）来呈现研究结果。
在过去4年里，我们在沙特阿拉伯南部的纳季兰研究了57例确诊的儿童布鲁氏菌病病例，平均每年约12例。其中，15.8%的病例报告有饮用生牛奶和食用乳制品的历史，只有1.8%的病例报告有动物接触史，而82.4%的病例确认传播途径不明。36.8%的病例仅表现为发热，21.1%的病例表现为发热和关节痛，19.3%的病例表现为发热和肌痛。三分之二的病例通过标准凝集试验（SAT）确诊。10.5%的病例出现肝脾肿大。利福平是首选抗生素，70.2%的病例已治愈，但3.5%的病例复发，1.8%的病例死于并发症。
结果表明，对于生活在流行地区、有发热症状且有饮用生牛奶和食用乳制品及/或动物接触史的儿童，应考虑布鲁氏菌病。预防应依靠对公众进行关于该疾病不同问题的健康教育，包括煮沸生牛奶。
