A Myth Still Needs to be Clarified: A Case Report of the Frank's Sign.

Despite advancements in diagnostic tools, physical signs such as xanthelasmata, arcus corneae, facial wrinkles, and gray hair are useful indicators of underlying diseases. The presence of bilateral diagonal earlobe creases (DELCs), also known as Frank's sign, correlates with a myriad of cardiovascular diseases such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease. The use of Frank's sign as a bedside predictor of underlying coronary artery disease is controversial among clinicians. We report a case of a patient with bilateral DELCs found to have significant coronary artery disease during diagnostic coronary angiography for recurrent chest pain.