Keeley F W, Johnson D J
Connect Tissue Res. 1987;16(3):259-68. doi: 10.3109/03008208709006980.
Glucocorticoids have been shown by others to increase the synthesis of elastin both in aortic tissue of embryo chicks and in cells derived from fetal ligamentum nuchae. This report describes the effects of hydrocortisone on the production of elastin in aortic tissue of developing chick embryos and chicks. While the effect of hydrocortisone on elastin synthesis is stimulatory in the 14 day chick embryo and the day-old chick, the same dose of this glucocorticoid has no effect on elastin production in the 7 day old chick and significantly inhibits synthesis of elastin in the 14 day old chick. These age-related alterations in elastin production in response to hydrocortisone cannot be attributed to an effect of the steroid on the pool size of the radioactively labelled amino acid used to measure elastin synthesis.
其他人已表明，糖皮质激素可增加胚胎小鸡主动脉组织和胎儿项韧带来源细胞中弹性蛋白的合成。本报告描述了氢化可的松对发育中的小鸡胚胎和雏鸡主动脉组织中弹性蛋白产生的影响。虽然氢化可的松对弹性蛋白合成的作用在14日龄小鸡胚胎和一日龄雏鸡中具有刺激作用，但相同剂量的这种糖皮质激素对7日龄雏鸡的弹性蛋白产生没有影响，并且显著抑制14日龄雏鸡中弹性蛋白的合成。这些与年龄相关的、对氢化可的松反应的弹性蛋白产生变化，不能归因于该类固醇对用于测量弹性蛋白合成的放射性标记氨基酸库大小的影响。
