Verstockt Bram, Deleenheer Barbara, Sermon Filip, Van Der Steen Kris, Vandervoort Jo
Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Translational Research in Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
Acta Gastroenterol Belg. 2017 Jul-Sep;80(3):416-418.
We present two cases of patients with severe persistent diarrhoea, in whom duodenal biopsies revealed villous atrophy that could be attributed to the use of olmesartan. The differential diagnosis of villous atrophy without serological markers of celiac disease should include drugs as possible cause, with olmesartan as a recently discovered culprit. Gastroenterologist should be aware of this entity.
我们报告了两例严重持续性腹泻患者，其十二指肠活检显示绒毛萎缩，这可能归因于奥美沙坦的使用。在无乳糜泻血清学标志物的情况下，绒毛萎缩的鉴别诊断应包括药物作为可能病因，奥美沙坦是最近发现的罪魁祸首。胃肠病学家应了解这一情况。
