Scharla S H, Minne H W, Sattar P, Mende U, Blind E, Schmidt-Gayk H, Wüster C, Ho T, Ziegler R
Dtsch Med Wochenschr. 1987 Jul 10;112(28-29):1121-5. doi: 10.1055/s-2008-1068205.
Clodronate (dichlormethylene diphosphonate) was administered to 21 patients with hypercalcemia due to malignant tumor. The drug was initially given intravenously, then orally. In 20 patients the serum calcium level had been reduced to the normal range within one week of the start of treatment (from 3.3 +/- 0.5 mmol/l to 2.4 +/- 0.3 mmol/l). With oral administration there was a renewed rise in calcium levels in some patients, which had to be treated with higher oral doses or intravenous administration. Parallel with the reduction in calcium levels there was an improvement in the originally impaired renal function. The serum level of intact parathormone(1-84) and 1.25-dihydroxy-vitamin-D3 (calcitriol) rose significantly from usually lowered initial levels. There was a non-linear inverse correlation between parathormone and calcium. No side effects were noted, even after long-term administration.
氯屈膦酸二钠（二氯亚甲基二膦酸盐）被给予21例因恶性肿瘤导致高钙血症的患者。药物最初通过静脉给药，然后改为口服。20例患者在治疗开始后的一周内血清钙水平已降至正常范围（从3.3±0.5毫摩尔/升降至2.4±0.3毫摩尔/升）。口服给药后，一些患者的钙水平再次升高，这不得不通过更高的口服剂量或静脉给药来治疗。随着钙水平的降低，原本受损的肾功能有所改善。完整甲状旁腺激素（1-84）和1,25-二羟基维生素D3（骨化三醇）的血清水平从通常较低的初始水平显著升高。甲状旁腺激素和钙之间存在非线性负相关。即使长期给药也未观察到副作用。
