Cazzo Everton, Pareja José Carlos, Chaim Elinton Adami, Coy Cláudio Saddy Rodrigues, Magro Daniéla Oliveira
Departamento de Cirurgia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brasil.
Arq Gastroenterol. 2018 Jan-Mar;55(1):72-77. doi: 10.1590/S0004-2803.201800000-14.
The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation.
To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls.
An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls. Postprandial levels of GLP-1, GLP-2, glucose, and insulin were obtained after a standard meal tolerance test. Inflammation was assessed by means of CRP.
There were 30 individuals enrolled in the study, divided into three groups: non-diabetic with morbid obesity (NDO; n=11 individuals), diabetic with mild obesity (T2D; n=12 individuals), and healthy controls (C; n=7 individuals). The mean CRP levels were significantly higher in the NDO group (6.6±4.7 mg/dL) than in the T2D (3.3±2.2 mg/dL) and C groups (2.5±3.2 mg/dL) (P=0.038). The GLP-1 levels following standard meal tolerance test and the area under the curve of GLP-1 did not differ among the three groups. The GLP-2 levels were significantly lower in the NDO and T2D than in the C group following standard meal tolerance test at all the times evaluated. The area under the curve of the GLP-2 was significantly lower in the NDO and T2D groups than in the C group (P=0.05 and P=0.01, respectively).
GLP-2 levels were impaired in the individuals with obesity and diabetes. This mechanism seems to be enrolled in preventing the worsening of the glucose homeostasis in these individuals.
胰高血糖素样肽1和2（GLP-1/GLP-2）是肠道激素，可能直接影响葡萄糖稳态，且它们的活性似乎受慢性炎症的显著影响。
评估肥胖症患者、2型糖尿病患者和健康对照者的餐后胰高血糖素样肽1和2（GLP-1/GLP-2）、C反应蛋白（CRP）水平以及餐后血糖和胰岛素水平。
一项探索性横断面研究，纳入等待减肥/代谢手术的患者和健康对照者。在标准餐耐量试验后获取GLP-1、GLP-2、葡萄糖和胰岛素的餐后水平。通过CRP评估炎症情况。
该研究共纳入30名个体，分为三组：非糖尿病伴病态肥胖者（NDO；n = 11人）、糖尿病伴轻度肥胖者（T2D；n = 12人）和健康对照者（C；n = 7人）。NDO组的平均CRP水平（6.6±4.7mg/dL）显著高于T2D组（3.3±2.2mg/dL）和C组（2.5±3.2mg/dL）（P = 0.038）。标准餐耐量试验后的GLP-1水平及GLP-1曲线下面积在三组之间无差异。在所有评估时间点，标准餐耐量试验后NDO组和T2D组的GLP-2水平均显著低于C组。NDO组和T2D组的GLP-2曲线下面积显著低于C组（分别为P = 0.05和P = 0.01）。
肥胖症和糖尿病患者的GLP-2水平受损。这种机制似乎参与了预防这些个体葡萄糖稳态的恶化。
