Departments of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA.
Departments of Pediatrics, and Microbiology & Immunology, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA.
Int J Mol Sci. 2018 Mar 19;19(3):909. doi: 10.3390/ijms19030909.
Discovering new drugs for treatment of invasive fungal infections is an enduring challenge. There are only three major classes of antifungal agents, and no new class has been introduced into clinical practice in more than a decade. However, recent advances in our understanding of the fungal life cycle, functional genomics, proteomics, and gene mapping have enabled the identification of new drug targets to treat these potentially deadly infections. In this paper, we examine amino acid transport mechanisms and metabolism as potential drug targets to treat invasive fungal infections, including pathogenic yeasts, such as species of and , as well as molds, such as . We also explore the mechanisms by which amino acids may be exploited to identify novel drug targets and review potential hurdles to bringing this approach into clinical practice.
发现治疗侵袭性真菌感染的新药是一个持久的挑战。目前只有三类主要的抗真菌药物，而且在过去十年中没有一类新药被引入临床实践。然而，最近我们对真菌生命周期、功能基因组学、蛋白质组学和基因图谱的理解的进展，使得识别新的药物靶点来治疗这些潜在致命的感染成为可能。在本文中，我们研究了氨基酸转运机制和代谢作为治疗侵袭性真菌感染的潜在药物靶点，包括致病性酵母，如 和 等物种，以及霉菌，如 等。我们还探讨了氨基酸可能被利用来识别新的药物靶点的机制，并回顾了将这种方法应用于临床实践的潜在障碍。
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