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产科患者中可回收下腔静脉滤器的应用

Retrievable inferior vena cava filter utilization in obstetric patients.

作者信息

Rottenstreich Amihai, Kalish Yosef, Elchalal Uriel, Klimov Alexander, Bloom Allan I

机构信息

a Department of Obstetrics and Gynecology , Hadassah-Hebrew University Medical Center , Jerusalem , Israel.

b Department of Hematology , Hadassah-Hebrew University Medical Center , Jerusalem , Israel.

出版信息

J Matern Fetal Neonatal Med. 2019 Sep;32(18):3045-3053. doi: 10.1080/14767058.2018.1456521. Epub 2018 Apr 2.

Abstract

The objective of this study is to evaluate patterns of use and outcomes of retrievable inferior vena cava filters (rIVCF) in obstetric patients. A single center review of consecutive patients who underwent rIVCF placement during pregnancy/postpartum in 2005-2016. A pooled analysis of the relevant cases in the English literature was conducted. The current cohort comprised 24 women, median age 27 [interquartile range 24-30] years. Among 10 filters placed during pregnancy, the most common indication ( = 4) was the need to withhold anticoagulation therapy before delivery, in the presence of acute thrombosis. In the postpartum period, most filters (64%, 9/14) were an adjunct to catheter-directed thrombolytic therapy. Inferior vena cava filters (IVCF)-related complications occurred in seven (29.2%). Retrieval was attempted in 21 patients (87.5%), and was technically successful in 19 (90.5%), for an overall removal rate of 79.1%. Pooled analysis of the literature ( = 98) showed comparable rates for filter removal and complications (81.6%,  = .78 and 24.2%,  = .60, respectively). Suprarenal placement ( = .12) and elective cesarean section ( = .19) did not reduce overall complication and retrieval rates. The estimated radiation dose among pregnant patients who underwent rIVCF placement without adjunct catheter directed thrombolysis (CDT) (mean 695 Gy cm) was significantly lower than the radiation dose used in postpartum patients (1863 Gy cm) or in pregnant patients in whom adjunct CDT was utilized (4059 Gy cm) ( = .001 for both comparisons). Frequent rIVCF-related complications, radiation exposure, and removal failure call for their cautious utilization in obstetric patients. The role of suprarenal placement and elective cesarean section to improve outcomes has yet to be established.

摘要

本研究的目的是评估产科患者中可取出下腔静脉滤器(rIVCF)的使用模式和结局。对2005年至2016年期间在妊娠/产后接受rIVCF置入的连续患者进行单中心回顾。对英文文献中的相关病例进行汇总分析。当前队列包括24名女性,中位年龄27岁[四分位间距24 - 30岁]。在孕期置入的10个滤器中,最常见的适应证(n = 4)是在急性血栓形成的情况下,分娩前需要停用抗凝治疗。在产后阶段,大多数滤器(64%,9/14)是导管定向溶栓治疗的辅助手段。下腔静脉滤器(IVCF)相关并发症发生在7例(29.2%)。21例患者(87.5%)尝试取出滤器,其中19例(90.5%)技术成功,总体取出率为79.1%。文献汇总分析(n = 98)显示滤器取出率和并发症发生率相当(分别为81.6%,P = 0.78和24.2%,P = 0.60)。肾上极置入(P = 0.12)和择期剖宫产(P = 0.19)并未降低总体并发症和取出率。在未接受辅助导管定向溶栓(CDT)的rIVCF置入妊娠患者中,估计的辐射剂量(平均695 Gy cm)显著低于产后患者(1863 Gy cm)或接受辅助CDT的妊娠患者(4059 Gy cm)(两项比较P均 = 0.001)。频繁的rIVCF相关并发症、辐射暴露和取出失败要求在产科患者中谨慎使用它们。肾上极置入和择期剖宫产在改善结局方面的作用尚未确立。

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