Van Eerdewegh M M, Van Eerdewegh P, Coryell W, Clayton P J, Endicott J, Koepke J, Rochberg N
J Affect Disord. 1987 May-Jun;12(3):223-32. doi: 10.1016/0165-0327(87)90031-0.
In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH Collaborative Study on the Psychobiology of Depression Clinical section: the schizo-bipolar (SBP, n = 45), the schizo-unipolar (SUP, n = 30), the bipolar I (BP, n = 159) and the primary unipolar depressed (UP, n = 387) defined by Research Diagnostic Criteria. Two dimensions were identified among the four groups of 'affective' patients: the 'bipolar' and the 'schizophrenic' dimensions. They provided highly significant discrimination among the means of the four groups but were not very accurate in predicting group membership. The 'bipolar' dimension separates the UP from the BP and SBP, the SUP taking some intermediate value. The 'schizophrenic' dimension separates the BP and UP from the SUP, the SBP being intermediate. The two groups with the most similarities were the SBP and BP. The group with the most heterogeneity was the SUP, sharing similarities with the UP and SBP mostly. These conclusions are supported by results of familial aggregation on the same group of patients.
为了解决分裂情感性障碍患者之间的异质性问题，单变量和多变量统计分析方法（典型判别分析）被应用于美国国立精神卫生研究所抑郁症心理生物学合作研究临床部分四组情感障碍患者的社会人口统计学和自然史变量：根据研究诊断标准定义的分裂双相型（SBP，n = 45）、分裂单相型（SUP，n = 30）、双相I型（BP，n = 159）和原发性单相抑郁型（UP，n = 387）。在四组“情感性”患者中识别出两个维度：“双相”维度和“精神分裂症”维度。它们在四组均值之间提供了高度显著的区分，但在预测组成员身份方面不太准确。“双相”维度将UP与BP和SBP区分开来，SUP取一些中间值。“精神分裂症”维度将BP和UP与SUP区分开来，SBP处于中间位置。最相似的两组是SBP和BP。异质性最高的组是SUP，主要与UP和SBP有相似之处。这些结论得到了同一组患者家族聚集结果的支持。
