脂联素在慢性血栓栓塞性肺动脉高压中的作用。
Adiponectin in Chronic Thromboembolic Pulmonary Hypertension.
机构信息
Department of Cardiology, Keio University School of Medicine.
出版信息
Circ J. 2018 Apr 25;82(5):1466-1468. doi: 10.1253/circj.CJ-17-1434. Epub 2018 Mar 21.
BACKGROUND
The correlation between serum adiponectin concentration and hemodynamics or certain metabolic markers in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is unknown.
METHODS AND RESULTS
We enrolled 30 CTEPH patients who underwent interventional therapy of balloon pulmonary angioplasty or pulmonary endarterectomy. Serum adiponectin concentrations positively correlated with B-type natriuretic peptide (BNP) concentrations, pulmonary vascular resistance, and mean pulmonary arterial pressure. After the therapeutic interventions, serum adiponectin concentrations improved and changes in serum adiponectin concentrations significantly correlated with changes in BNP concentrations.
CONCLUSIONS
Adiponectin can be a useful marker for the severity of CTEPH.
背景
在慢性血栓栓塞性肺动脉高压（CTEPH）患者中，血清脂联素浓度与血液动力学或某些代谢标志物之间的相关性尚不清楚。
方法和结果
我们纳入了 30 例接受球囊肺动脉成形术或肺动脉内膜切除术介入治疗的 CTEPH 患者。血清脂联素浓度与 B 型利钠肽（BNP）浓度、肺血管阻力和平均肺动脉压呈正相关。治疗干预后，血清脂联素浓度改善，血清脂联素浓度的变化与 BNP 浓度的变化显著相关。
结论
脂联素可作为 CTEPH 严重程度的有用标志物。
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