托利普罗林醇，一种来自鞘孢菌属 FKI-7981 的新二肽。

Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981.

机构信息

Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2018 Jul;71(7):682-684. doi: 10.1038/s41429-018-0041-3. Epub 2018 Mar 22.

DOI:10.1038/s41429-018-0041-3

PMID:29563600

Abstract

A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-L-phenylalanyl-L-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.

摘要

一种新的二肽，命名为托普利醇，是从真菌 Tolypocladium sp. FKI-7981 的静态培养中分离得到的。托普利醇的结构被阐明为 N-乙酰-L-苯丙氨酰-L-脯氨酸。它表现出中等的抗疟活性，但没有显示细胞毒性或任何其他抗菌特性。