由 Simplicillium sp. FKI-5985 产生的 Aogacillins A 和 B：耐万古霉素金黄色葡萄球菌中阿贝卡星耐药性的新规避因子。
Aogacillins A and B produced by Simplicillium sp. FKI-5985: new circumventors of arbekacin resistance in MRSA.
机构信息
Faculty of Pharmaceutical Sciences, Tokyo University of Science , 2641 Yamazaki, Noda, Chiba, 278-8510, Japan, Kitasato Institute for Life Sciences, Kitasato University , 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, School of Pharmacy, Kitasato University , 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan, and Hall-Atwater Laboratories of Chemistry, Wesleyan University , Middletown, Connecticut 06459-0180, United States.
出版信息
Org Lett. 2013 Sep 20;15(18):4678-81. doi: 10.1021/ol401975z. Epub 2013 Sep 4.
Aogacillins A and B, capable of overcoming arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA), were isolated from a culture broth of Simplicillium sp. FKI-5985. Their structures were elucidated by NMR spectroscopic studies and ECD analyses. The aogacillins possessed a novel carbon skeleton, including a β-keto-γ-methyliden-δ-lactone ring connected to a 2-ethyl-6-methylcyclohexane ring by spiro conjugation.
Aogacillins A 和 B 能够克服耐甲氧西林金黄色葡萄球菌 (MRSA) 对阿贝卡星的耐药性，从棘孢木霉 FKI-5985 的发酵液中分离得到。它们的结构通过 NMR 波谱研究和 ECD 分析得到阐明。aogacillins 具有新颖的碳骨架，包括通过螺环共轭连接到 2-乙基-6-甲基环己烷环的β-酮-γ-亚甲基-δ-内酰胺环。
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