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一例因患儿存在弱D(D抗原未知)抗原导致的新生儿溶血病罕见病例。

A rare case of hemolytic disease of newborn due to weak D (D unknown) antigen in child.

作者信息

Dava Nirav Ramesh, Upadhyaya Alok, Agarwal Neha, Mehta Amarjeet, Choudhary Vijaypal, Goyal Gourav

机构信息

Department of Paediatrics, SMS Medical College and Attached J K Lon Hospital, Jaipur, Rajasthan, India.

出版信息

Asian J Transfus Sci. 2018 Jan-Jun;12(1):75-77. doi: 10.4103/ajts.AJTS_21_17.

Abstract

We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3 order male child of GPA mother was admitted at 8 h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D antigen was positive in baby. Hematological parameters showed all the signs of ongoing hemolysis, and the bilirubin level was in the zone of exchange transfusion. Exchange transfusion was done. An intravenous immunoglobulin was given to child after that. Mother had a history of first normal healthy male child with O Rh D positive blood group. Second male child expired on 3 postnatal day due to bilirubin encephalopathy that had A Rh D negative blood group with positive direct coombs test.

摘要

我们报告了一例罕见的新生儿溶血病,患儿存在弱D抗原。一名GPA母亲的三级男婴出生8小时因黄疸入院。母婴血型均为A Rh D阴性。婴儿的直接抗人球蛋白试验呈阳性。婴儿的弱D抗原呈阳性。血液学参数显示出持续溶血的所有迹象,胆红素水平处于换血范围。进行了换血治疗。之后给患儿静脉注射了免疫球蛋白。母亲有一个健康的第一胎男婴,血型为O Rh D阳性。第二个男婴出生后第3天因胆红素脑病死亡,其血型为A Rh D阴性,直接抗人球蛋白试验呈阳性。

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本文引用的文献

1
A new Rh allelomorph.一种新的Rh等位基因。
Nature. 1946 Jul 6;158:25. doi: 10.1038/158025c0.
2
Weak D prevalence among Indian blood donors.印度献血者中弱D抗原的流行情况。
Asian J Transfus Sci. 2010 Jul;4(2):137-9. doi: 10.4103/0973-6247.67030.

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