Ng Jessica Y, Gu Jennie
Surgery, Gold Coast University Hospital.
Cureus. 2018 Jan 20;10(1):e2092. doi: 10.7759/cureus.2092.
Acute acalculous cholecystitis is an uncommon disease in children and is usually associated with trauma, burns, and infections. Whereas acute acalculous cholecystitis is only seen in 10% of cholecystitis in adults, it is uncommon in the paediatric population. A seven-year-old male presented to the emergency department of a regional hospital with a 36-hour history of right-upper-quadrant abdominal pain. He had associated symptoms of anorexia, nausea, and vomiting. He was septic with raised white cell count and inflammatory markers. Diffuse gallbladder wall thickening without intraluminal sludge or calculi was seen on abdominal ultrasound. He was found to have a concurrent right-upper lobe pneumonia on further investigation. The patient was treated with antibiotics and responded well to supportive and conservative management with close radiological monitoring. Acute acalculous cholecystitis is associated with a high mortality rate (30%) and significant complications such as gangrene, empyema, and perforation in 40% of adult cases. Acute surgical management has been traditionally advocated, however, surgery is not without risks; studies have suggested that non-operative intervention may be appropriate for selected critically ill children with an underlying cause. Herein, we discuss the safe and effective conservative treatment of acute acalculous cholecystitis in lieu of operative management and highlight the importance of recognising this disease in paediatric patients with acute abdominal pain and coexisting infection.
急性非结石性胆囊炎在儿童中是一种罕见疾病,通常与创伤、烧伤和感染有关。虽然急性非结石性胆囊炎仅见于10%的成人胆囊炎患者,但在儿科人群中并不常见。一名7岁男性因右上腹腹痛36小时就诊于一家地区医院急诊科。他伴有厌食、恶心和呕吐症状。他出现脓毒症,白细胞计数和炎症标志物升高。腹部超声显示胆囊壁弥漫性增厚,无腔内淤泥或结石。进一步检查发现他同时患有右上叶肺炎。该患者接受了抗生素治疗,并在密切的影像学监测下对支持性和保守治疗反应良好。急性非结石性胆囊炎的死亡率较高(30%),在40%的成人病例中会出现坏疽、积脓和穿孔等严重并发症。传统上主张进行急性手术治疗,然而,手术并非没有风险;研究表明,对于某些有潜在病因的危重症儿童,非手术干预可能是合适的。在此,我们讨论了代替手术治疗的急性非结石性胆囊炎的安全有效保守治疗方法,并强调了在患有急性腹痛和并存感染的儿科患者中识别这种疾病的重要性。