Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax University, 3029, Sfax, Tunisia.
Department of Biology, Faculty of Sciences of Gabès University, Zrig, 6072, Gabès, Tunisia.
Environ Sci Pollut Res Int. 2018 Jun;25(16):15404-15410. doi: 10.1007/s11356-018-1640-z. Epub 2018 Mar 21.
Our study was designed to evaluate impacts of exposure to pollutants, released by the Gabès-Ghannouche factory complex of phosphate treatment, on biochemical biomarkers and histopathological indices in kidney tissues of Hybrid sparrow (Passer domesticus × Passer hispaniolensis) in Gabès city. Our results show evidence of a pronounced impairment in kidney function which is confirmed by remarkable blood chemical alterations in sparrows living in Ghannouche, the most polluted site. Moreover, superoxide dismutase and catalase activities were found to be decreased in birds sampled from the contaminated site when compared to less polluted areas. The population of sparrows feeding in Ghannouche had enhanced renal thiobarbituric acid reactive substance levels, indicating oxidative damage to membrane lipids. Some histopathological alterations were also observed including kidney interstitial dilatations. Overall, our findings demonstrated that the exposure to pollutants released by the factory complex possessed nephrotoxic by depleting renal antioxidant defense system and promoting kidney morphometric damage in sparrows. These results constitute an early warning of an ecological change in relation to human health.
我们的研究旨在评估加贝斯-加努什磷酸盐处理厂复合体释放的污染物对杂种麻雀（家麻雀×西班牙麻雀）肾脏组织中生化生物标志物和组织病理学指标的影响。我们的结果表明，在加努什污染最严重的地区，麻雀的肾功能明显受损，这一点得到了血液化学明显改变的证实。此外，与污染较少的地区相比，从污染地区采集的鸟类中超氧化物歧化酶和过氧化氢酶的活性降低。在加努什觅食的麻雀的肾丙二醛含量增加，表明膜脂质受到氧化损伤。还观察到一些组织病理学改变，包括肾间质扩张。总的来说，我们的研究结果表明，暴露于工厂复合体释放的污染物会通过耗尽肾脏抗氧化防御系统和促进麻雀肾脏形态损伤而具有肾毒性。这些结果构成了与人类健康有关的生态变化的早期预警。
