Assunção Silvana Neves Ferraz de, Sorte Ney Christian Amaral Boa, Alves Crésio De Aragão Dantas, Mendes Patrícia S Almeida, Alves Carlos Roberto Brites, Silva Luciana Rodrigues
Universidade Federal da Bahia.
Nutr Hosp. 2018 Jan 16;35(1):78-83. doi: 10.20960/nh.1317.
Non-alcoholic fatty liver disease is characterized by the intrahepatic deposition of fat. It is the most prevalent liver disease in the world, affecting obese children and adolescents. Its pathophysiology is not fully understood, although it is often related to insulin resistance. This in turn would be due to an inflammatory condition common to obesity. Thus, the objective of this study was to describe the behavior of proinflammatory cytokines in obese children and adolescents, with and without non-alcoholic fatty liver disease.
A fasting venous blood sample was obtained of consecutive 90 obese individuals aged 8-18 years, of both sexes, for laboratory determinations of glycaemia, basal insulin and homeostasis model assessment insulin-resistance index, and the inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukins 2 and 6 (IL-2 and IL-6), interferon-gamma and high sensitive C-reactive protein. The clinical evaluation included weight, height and waist circumference. We used the body mass index/age indicator for the severity of overweight assessment. The degrees of steatosis were determined by ultrasonography. Quantitative and qualitative variables were respectively expressed by measures of central tendency/dispersion and simple/relative frequency, using Statistical Program for Social Sciences, version 20.0. A p-value < 0.05 was considered as significant.
A total of 90 individuals were studied, with a mean age of 11.98 (2.72) years, of which 48 (53%) were male. The body mass index (BMI) for age (BMI/i) and sex (z-score) classified 38 (42.2%) participants as obese and 52 (57.7%) as severe obese; Hepatic steatosis was identified in 56 (62.2%) participants and approximately 90% of them presented grade I steatosis. The inflammatory markers TNF-α, and C-reactive protein were increased in the studied sample and correlated in a positive and statistically significant way with the index of body mass/age and sex.
Hepatic steatosis was prevalent in the group of children and adolescents studied, but was not related to obesity degrees.
非酒精性脂肪性肝病的特征是肝内脂肪沉积。它是世界上最普遍的肝脏疾病，影响肥胖儿童和青少年。尽管其病理生理学常与胰岛素抵抗有关，但其尚未被完全理解。这反过来可能是由于肥胖常见的炎症状态所致。因此，本研究的目的是描述有和没有非酒精性脂肪性肝病的肥胖儿童和青少年中促炎细胞因子的表现。
采集了连续90名年龄在8至18岁的肥胖个体（男女均有）的空腹静脉血样本，用于实验室测定血糖、基础胰岛素和稳态模型评估胰岛素抵抗指数，以及炎症标志物肿瘤坏死因子-α（TNF-α）、白细胞介素2和6（IL-2和IL-6）、干扰素-γ和高敏C反应蛋白。临床评估包括体重、身高和腰围。我们使用体重指数/年龄指标来评估超重的严重程度。通过超声检查确定脂肪变性的程度。使用社会科学统计程序20.0版分别用集中趋势/离散度测量和简单/相对频率来表示定量和定性变量。p值<0.05被认为具有统计学意义。
共研究了90名个体，平均年龄为11.98（2.72）岁，其中48名（53%）为男性。年龄体重指数（BMI/i）和性别（z评分）将38名（42.2%）参与者分类为肥胖，52名（57.7%）为重度肥胖；56名（62.2%）参与者被发现有肝脂肪变性，其中约90%表现为I级脂肪变性。研究样本中炎症标志物TNF-α和C反应蛋白升高，并且与体重/年龄和性别指数呈正相关且具有统计学意义。
在所研究的儿童和青少年群体中肝脂肪变性很普遍，但与肥胖程度无关。
