Digestive Department of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Eur Rev Med Pharmacol Sci. 2018 Mar;22(5):1397-1401. doi: 10.26355/eurrev_201803_14485.
This aim of this study is to investigate the diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic lesions.
Patients with pancreatic lesions after CT (or MRI) and EUS-FNA examination were retrospectively enrolled. Cytopathological diagnosis of pancreas tissue were obtained by surgery or EUS-FNA. Clinical follow-up results were used as golden standard for diagnosis of pancreatic lesions. Statistical analysis was performed by Student's t-test for continuous data and Fischer exact test for categorical data.
A total of 18 patients with pancreatic lesions were included in this study, 7 of which were diagnosed as benign lesions and 11 were diagnosed as malignant lesions. Endoscopic ultrasonography (ESU) showed that most of the lesions were in pancreatic body (42.9%), followed by pancreatic head, pancreatic tail, and pancreatic neck. The maximum diameter of malignant lesions was larger compared with that of benign and the difference was statistically significant (p < 0.05). The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of EUS-FNA for differentiating diagnosis of malignant and benign pancreatic lesions was 83.3%, 80%, 83.3%, 90.9%, and 71.4%, respectively.
EUS-FNA cytological diagnosis is safe and effective for differentiating diagnosis of malignant and benign pancreatic lesions.
本研究旨在探讨超声内镜引导下细针抽吸（EUS-FNA）在胰腺病变中的诊断性能。
回顾性纳入经 CT（或 MRI）和 EUS-FNA 检查后患有胰腺病变的患者。通过手术或 EUS-FNA 获取胰腺组织的细胞学诊断。临床随访结果被用作胰腺病变诊断的金标准。通过学生 t 检验进行连续数据的统计分析，通过 Fisher 确切检验进行分类数据的统计分析。
本研究共纳入 18 例胰腺病变患者，其中 7 例诊断为良性病变，11 例诊断为恶性病变。超声内镜（EUS）显示，大多数病变位于胰体（42.9%），其次是胰头、胰尾和胰颈。恶性病变的最大直径大于良性病变，差异有统计学意义（p<0.05）。EUS-FNA 对鉴别诊断恶性和良性胰腺病变的灵敏度、特异性、准确性、阳性预测值（PPV）和阴性预测值（NPV）分别为 83.3%、80%、83.3%、90.9%和 71.4%。
EUS-FNA 细胞学诊断对于鉴别诊断恶性和良性胰腺病变是安全有效的。
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