St-Patrick Research Group in Basic Oncology, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Centre (L'Hôtel-Dieu de Québec), Laval University Cancer Research Centre, Québec City, Québec, Canada.
FASEB J. 2018 Aug;32(8):4070-4084. doi: 10.1096/fj.201701536R. Epub 2018 Mar 22.
The surface of endothelial cells is covered with cell adhesion molecules, including E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM- 1) , that mediate the adhesion and extravasation of leukocytes and play pivotal roles in inflammatory response. microRNAs (miRNAs) regulate the expression of these important cell adhesion molecules through two distinct major mechanisms, namely via modulating the proinflammatory NF-κB pathway, which controls their transcription, and via directly targeting them. The present review highlights the role of various miRNAs in controlling the expression of E-selectin, ICAM-1, and VCAM-1: a type of regulation that can be harnessed for therapeutic prevention of inflammation-associated diseases such as atherosclerosis and sepsis. The roles of secreted miRNAs as paracrine regulators, and cell adhesion molecule-based miRNA delivery are also addressed.-Zhong, L., Simard, M. J., Huot, J. Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation.
内皮细胞的表面覆盖着细胞黏附分子，包括 E-选择素、细胞间黏附分子 1（ICAM-1）和血管细胞黏附分子 1（VCAM-1），它们介导白细胞的黏附和渗出，在炎症反应中起着关键作用。微小 RNA（miRNA）通过两种不同的主要机制调节这些重要的细胞黏附分子的表达，即通过调节控制其转录的促炎 NF-κB 途径，以及通过直接靶向它们。本综述强调了各种 miRNA 在控制 E-选择素、ICAM-1 和 VCAM-1 表达中的作用：这种调节可以用于治疗与炎症相关的疾病，如动脉粥样硬化和败血症。分泌型 miRNA 作为旁分泌调节剂的作用，以及基于细胞黏附分子的 miRNA 传递也得到了探讨。
