头颈部黑色素瘤中肿瘤有丝分裂率和缺乏表皮附着的临床意义。
Clinical significance of tumor mitotic rate and lack of epidermal attachment in melanoma of the head and neck.
机构信息
Case Western Reserve University School of Medicine, Cleveland, Ohio.
Department of Otolaryngology, Ear, Nose, and Throat Institute, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
出版信息
Head Neck. 2018 Aug;40(8):1691-1696. doi: 10.1002/hed.25153. Epub 2018 Mar 22.
BACKGROUND
The primary purpose of this study was to identify the prognostic role of primary dermal melanoma and tumor mitotic rate in melanomas of the head and neck.
METHODS
A retrospective review of the histopathologic, clinical, and demographic data of 256 patients was performed to investigate the impact of primary dermal melanoma and tumor mitotic rate on sentinel lymph node positivity, recurrence, and 5-year overall and disease-free survival.
RESULTS
Increased tumor mitotic rate, but not primary dermal melanoma, is a significant predictor of sentinel lymph node positivity and higher likelihood of recurrence. Survival analysis demonstrated that both increased tumor mitotic rate and primary dermal melanoma decreased the 5-year overall and disease-free survival rates of patients with head and neck melanoma lesions.
CONCLUSION
Tumor mitotic rate and primary dermal melanoma may have prognostic significance for both overall and disease-free survival in patients with head and neck melanoma. A larger prospective study is warranted to further elucidate prognostic factors for melanoma in the head and neck region.
背景
本研究的主要目的是确定原发性皮肤黑色素瘤和肿瘤有丝分裂率在头颈部黑色素瘤中的预后作用。
方法
对 256 例患者的组织病理学、临床和人口统计学数据进行回顾性分析，以探讨原发性皮肤黑色素瘤和肿瘤有丝分裂率对前哨淋巴结阳性、复发以及 5 年总生存率和无病生存率的影响。
结果
肿瘤有丝分裂率的增加，而不是原发性皮肤黑色素瘤，是前哨淋巴结阳性和更高复发可能性的显著预测因素。生存分析表明，肿瘤有丝分裂率的增加和原发性皮肤黑色素瘤均降低了头颈部黑色素瘤患者的 5 年总生存率和无病生存率。
结论
肿瘤有丝分裂率和原发性皮肤黑色素瘤可能对头颈部黑色素瘤患者的总生存率和无病生存率具有预后意义。需要更大的前瞻性研究来进一步阐明头颈部黑色素瘤的预后因素。
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