Alio Jorge L, Rodriguez Alejandra E, De Arriba Pablo, Gisbert Sandra, Abdelghany Ahmed A
1 Research, Development and Innovation Department, VISSUM, Alicante, Spain.
3 Faculty of Medicine, Miguel Hernandez University, Alicante, Spain.
Eur J Ophthalmol. 2018 Sep;28(5):515-520. doi: 10.1177/1120672117747042. Epub 2018 Mar 23.
To assess the effectiveness of autologous platelet-rich plasma for the treatment of dormant corneal ulcers secondary to corneal surgery and unresponsive to conventional treatment.
VISSUM, Ophthalmology Institute of Alicante, Alicante, Spain.
Prospective nonrandomized, observational consecutive study.
A total of 44 eyes of 28 patients with dormant corneal ulcers secondary to corneal surgery were included in a prospective study and treated with autologous platelet-rich plasma during 6 weeks. Wilcoxon signed-rank test was used to compare the effect of the treatment.
In all, 28 patients (65.1%) improved their visual acuity at least one line in Snellen chart, 26 (59.09%) had a decrease in the size of the ulcer or even a total closure, and 40 (90.9%) experienced an improvement in their symptoms. The results are also provided for the four groups of patients (keratoplasty, refractive surgery, cross-linking, and chronic postsurgical corneal edema).
Platelet-rich plasma eye drops shows to be a good option for the treatment of dormant corneal ulcers secondary to corneal surgery.
评估自体富血小板血浆治疗角膜手术后继发的、对传统治疗无反应的静止性角膜溃疡的有效性。
西班牙阿利坎特市阿利坎特眼科研究所VISSUM。
前瞻性非随机、观察性连续研究。
对28例角膜手术后继发静止性角膜溃疡患者的44只眼进行前瞻性研究，并在6周内使用自体富血小板血浆进行治疗。采用Wilcoxon符号秩检验比较治疗效果。
总体而言，28例患者（65.1%）的视力在斯内伦视力表上至少提高了一行，26例（59.09%）溃疡面积减小甚至完全愈合，40例（90.9%）症状有所改善。还给出了四组患者（角膜移植术、屈光手术、交联和慢性术后角膜水肿）的结果。
富血小板血浆滴眼液是治疗角膜手术后继发静止性角膜溃疡的一个良好选择。
