Department of Pharmaceutical Sciences and Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), 3 de Maio, 100, 04044-020, São Paulo, SP, Brazil.
Biological Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas, CP 6154, 13083-970, Campinas, SP, Brazil; NanoBioss, Institute of Chemistry, Universidade Estadual de Campinas, Campinas, SP, Brazil; LNNano (CNPEM), Campinas, SP, Brazil.
Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):649-656. doi: 10.1016/j.bpg.2017.10.002. Epub 2017 Oct 12.
Chromobacterium violaceum is a Gram negative, β-proteobacterium found in the microbiota of tropical and subtropical environments. Although considered an opportunistic pathogen, infection rapidly progress to fatal sepsis, with metastatic abscesses. It is noteworthy the multidrug resistant phenotype of C. violaceum and the possibility of relapse. Recently, an influence of global climate in the incidence of cases beyond the previous areas has been observed. Furthermore, chronic granulomatous disease has been considered a risk factor to infection. Despite the increase in C. violaceum infection incidence and high mortality, most clinicians are not familiar with it. This review pointed out important features of this life threatening microorganism, including its pathogenicity, mechanistic aspects, genetic and drug resistance associated factors, and the clinical association with chronic granulomatous disease. In addition, its main metabolite violacein may be a promising agent to counteract gastroenterological diseases, such as colorectal cancer and inflammatory gastric lesions.
紫色色杆菌是一种革兰氏阴性、β 变形菌，存在于热带和亚热带环境的微生物群中。尽管被认为是一种机会性病原体，但感染会迅速发展为致命的败血症，并伴有转移性脓肿。值得注意的是，紫色色杆菌具有多药耐药表型和复发的可能性。最近，人们观察到全球气候对发病地区的影响超出了以往的范围。此外，慢性肉芽肿病被认为是感染的一个危险因素。尽管 C. 紫色色杆菌感染的发病率和死亡率很高，但大多数临床医生并不熟悉它。这篇综述指出了这种危及生命的微生物的重要特征，包括其致病性、机制方面、与遗传和耐药性相关的因素，以及与慢性肉芽肿病的临床关联。此外，其主要代谢产物紫色色原可能是对抗胃肠道疾病（如结直肠癌和炎症性胃病变）的有前途的药物。
