CHL1基因多态性增加肺癌易感性。
CHL1 gene polymorphisms increase lung cancer susceptibility.
作者信息
Tian Wen, Li Xuelian, Ren Yangwu, Yin Zhihua, Quan Xiaowei, Zheng Chang, Zhou Baosen
机构信息
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Department of Education, Liaoning, Shenyang, China.
出版信息
Oncotarget. 2018 Jan 6;9(17):13545-13550. doi: 10.18632/oncotarget.24057. eCollection 2018 Mar 2.
Lung cancer represents a complex and malignant cancer. Close Homologue of L1 (CHL1) gene plays a crucial role in the progress of cancer. The aim of this study is to explore the association between CHL1 rs425366 polymorphism and lung cancer susceptibility in northeast of China. A hospital-based case-control study was carried out to collect relative characteristics. Logistic regression analysis was conducted to analyze the relationship between single nucleotide polymorphisms and lung cancer susceptibility. The results suggested that there was statistically significant difference between GT genotype and TT genotype of rs425366 and lung cancer susceptibility. In stratified analysis, TT genotype of rs425366 may increase the risk of lung adenocarcinoma. We also found that non-smoking individuals carrying T allele were more likely to develop lung cancer. Overall, our study may indicate that CHL1 gene may increase lung cancer susceptibility in northeast of China.
肺癌是一种复杂的恶性肿瘤。L1基因的紧密同源物（CHL1）基因在癌症进展中起关键作用。本研究旨在探讨中国东北地区CHL1 rs425366多态性与肺癌易感性之间的关联。开展了一项基于医院的病例对照研究以收集相关特征。进行逻辑回归分析以分析单核苷酸多态性与肺癌易感性之间的关系。结果表明，rs425366的GT基因型与TT基因型在肺癌易感性方面存在统计学显著差异。在分层分析中，rs425366的TT基因型可能增加肺腺癌风险。我们还发现携带T等位基因的非吸烟个体更易患肺癌。总体而言，我们的研究可能表明CHL1基因可能增加中国东北地区的肺癌易感性。
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