Vaeth Martin, Feske Stefan
Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA.
F1000Res. 2018 Mar 2;7:260. doi: 10.12688/f1000research.13426.1. eCollection 2018.
Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca /calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and many other tissues. In this review, we will discuss novel roles of NFAT in T cells, focusing mainly on its function in humoral immune responses, immunological tolerance, and the regulation of immune metabolism.
活化T细胞核因子（NFAT）几乎在三十年前首次被描述为T细胞中一种受钙/钙调神经磷酸酶调节的转录因子。从那时起，大量研究揭示了不同NFAT同源物在免疫系统和许多其他组织中的调控及生理功能。在本综述中，我们将讨论NFAT在T细胞中的新作用，主要聚焦于其在体液免疫反应、免疫耐受和免疫代谢调节中的功能。
Zotero 插件
