Cavatorta Emanuela, Voskuhl Jens, Wasserberg Dorothee, Brinkmann Jenny, Huskens Jurriaan, Jonkheijm Pascal
Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, Department of Science and Technology, University of Twente, P. O. Box 217, 7500 AE, Enschede, The Netherlands. Email:
Medical Cell BioPhysics Group, MIRA Biomedical Technology and Technical Medicine, Department of Science and Technology, University of Twente, Enschede, The Netherlands.
RSC Adv. 2017 Nov 29;7(86):54341-54346. doi: 10.1039/c7ra10980f. Epub 2017 Nov 27.
Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targeting ligands. These vesicles were employed for loading and delivery of proteins into cells. Supramolecular amphiphile-derived vesicles show great promise as nanocarriers of functional molecules to be transferred into cells.
超分子两亲物由葫芦[8]脲（CB[8]）、烷基化百草枯衍生物和四甘醇功能化偶氮苯的三元复合物组成，自组装成直径约200纳米的囊泡。囊泡的外表面用细胞靶向配体进行了功能化修饰。这些囊泡用于将蛋白质载入细胞并递送至细胞内。超分子两亲物衍生的囊泡作为将功能分子转移到细胞中的纳米载体显示出巨大的应用前景。
