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日本首例由……引起的败血症病例报告。 (原文中“by”后面缺少具体内容)

First case report of sepsis caused by in Japan.

作者信息

Kuchibiro Tomokazu, Hirayama Katsuhisa, Houdai Katsuyuki, Nakamura Tatsuya, Ohnuma Kenichirou, Tomida Junko, Kawamura Yoshiaki

机构信息

Department of Clinical Laboratory, Naga Municipal Hospital, 1282 Uchita, Kinokawa, Wakayama, 649-6414, Japan.

Department of Neurosurgery Medicine, Naga Municipal Hospital, 1282 Uchita, Kinokawa, Wakayama, 649-6414, Japan.

出版信息

JMM Case Rep. 2018 Jan 10;5(1):e005135. doi: 10.1099/jmmcr.0.005135. eCollection 2018 Jan.

Abstract

INTRODUCTION

Species of the genus are opportunistic, usually saprophytic, glucose-non-fermenting, Gram-negative bacilli found in agricultural soil. infections are the least common infections and have low incidence.

CASE PRESENTATION

Herein, we report the first case of sepsis with in Japan in a 67-year-old Japanese woman with a history of hyperlipidaemia, hypertension, diabetes, hypothyroidism and osteoporosis. She had undergone cerebrovascular treatment because she was diagnosed with a subarachnoid haemorrhage. The results of postoperative blood culture showed oxidase-positive, urease-positive, non-lactose-fermenting Gram-stain-negative rods. Using the Vitek2 system, the isolate was distinctly identified as . However, 16S rRNA gene sequencing showed 99.93 % similarity with the type strain of and 99.06 % similarity with the type strain of . Additional gene sequencing analysis using (97.2 %) and (96.2 %) also showed that the isolated strain is most closely related to . The patient was cured by treatment using intravenous meropenem (3 g/d) for 4 weeks and was discharged safely.

CONCLUSION

The definite source of sepsis was unknown. However, the possibility of having been infected through the catheter during the cerebrovascular operation was speculated.

摘要

引言

该属菌种为机会致病菌,通常腐生,不发酵葡萄糖,革兰氏阴性杆菌,存在于农业土壤中。感染是最不常见的感染类型,发病率较低。

病例报告

在此,我们报告日本首例67岁日本女性因感染导致败血症的病例,该女性有高脂血症、高血压、糖尿病、甲状腺功能减退和骨质疏松病史。她因诊断为蛛网膜下腔出血接受了脑血管治疗。术后血培养结果显示为氧化酶阳性、脲酶阳性、不发酵乳糖的革兰氏染色阴性杆菌。使用Vitek2系统,该分离株被明确鉴定为。然而,16S rRNA基因测序显示与的模式菌株相似度为99.93%,与的模式菌株相似度为99.06%。使用(97.2%)和(96.2%)进行的额外基因测序分析也表明,分离菌株与关系最为密切。患者通过静脉注射美罗培南(3g/d)治疗4周后治愈并安全出院。

结论

败血症的确切来源不明。然而,推测可能是在脑血管手术期间通过导管感染。

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