Ayesh Basim Mohammad, Abu Shaaban Ahmed Shaker, Abed Abdalla Asaf
Department of Laboratory Medical Sciences, Faculty of Applied Sciences, Alaqsa University, Gaza, Palestine.
Abdul Aziz al Rantisi Paediatric Hospital Laboratory, Ministry of Health, Gaza, Palestine.
Future Sci OA. 2018 Jan 10;4(3):FSO276. doi: 10.4155/fsoa-2017-0112. eCollection 2018 Mar.
To evaluate applicability of , and based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.
PATIENTS & METHODS: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.
Frequency of , and alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7).
The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.
评估基于 、 和 的算法在一组巴勒斯坦患者中预测华法林稳定剂量（WSD）的适用性。
回顾性计算了101例接受华法林治疗的巴勒斯坦患者使用三种模型的华法林剂量。在47例确定服用WSD的患者中评估了这三种模型的性能。
、 和 等位基因的频率分别为13.6%、0.0%和46.5%。国际华法林药物遗传学联盟算法比临床算法（平均绝对误差 [MAE]=10.4±1.4；R=0.128）和固定剂量算法（MAE=11.1±1.7）更可靠（MAE=8.9±1.4；R=0.350）。
国际华法林药物遗传学联盟算法可可靠地应用于预测巴勒斯坦人群的WSD。
