Scriven A J, Lipkin D P, Anand I S, Sutton G C, Poole-Wilson P A
Am J Cardiol. 1987 Aug 14;60(5):68C-71C. doi: 10.1016/0002-9149(87)90529-7.
A double-blind, randomized, crossover trial was undertaken to compare the effect of enoximone (150 mg, 3 times daily) and captopril (25 mg, 3 times daily) added to conventional therapy with diuretics in the treatment of 13 patients with severe chronic heart failure. Each treatment was continued for 1 month. Heart failure was due to idiopathic dilated cardiomyopathy in 6 patients and coronary artery disease in 7. Hemodynamic measurements were made at rest and during exercise, on entry to the study and after each treatment period. The cardiac index at rest was 1.9 +/- 0.2 liters min-1 m2 (mean +/- 1 standard deviation) and did not change with either drug. Systemic vascular resistance at rest decreased with enoximone (p less than 0.05) and was unchanged with captopril. Systemic vascular resistance at peak exercise was not lowered by either drug. Both drugs caused an increase of cardiac index at peak exercise (p less than 0.04) and a prolongation of exercise time (p less than 0.05). No difference was detected between the hemodynamic response to the 2 drugs after 1 month treatment either at rest or during exercise.
进行了一项双盲、随机、交叉试验，以比较在常规利尿剂治疗基础上加用依诺昔酮（150毫克，每日3次）和卡托普利（25毫克，每日3次）对13例重度慢性心力衰竭患者的治疗效果。每种治疗持续1个月。6例患者的心力衰竭病因是特发性扩张型心肌病，7例是冠状动脉疾病。在研究开始时以及每个治疗期后，于静息和运动时进行血流动力学测量。静息时心脏指数为1.9±0.2升·分钟⁻¹·平方米（平均值±1标准差），两种药物对此均无影响。静息时全身血管阻力依诺昔酮使其降低（p<0.05），卡托普利则无变化。两种药物均未降低运动高峰时的全身血管阻力。两种药物均使运动高峰时心脏指数增加（p<0.04），并延长运动时间（p<0.05）。治疗1个月后，在静息或运动时，两种药物的血流动力学反应未检测到差异。
