Kerut Edmund K, Turner Michael
Division of Cardiovascular Diseases, Department of Medicine, University of Mississippi School of Medicine, Jackson, MS, USA.
Heart Clinic of Louisiana, Marrero, LA, USA.
Echocardiography. 2018 May;35(5):730-732. doi: 10.1111/echo.13867. Epub 2018 Mar 22.
Coronary computed tomography angiography (CCTA) has been an established noninvasive method for detection of coronary artery disease (CAD). Although CCTA has had a high sensitivity and negative predictive value for CAD detection, specificity for obstructive CAD has been relatively low, partly due to coronary calcium, imaging artifacts, and other factors leading to an overestimation of stenosis severity. A relatively new noninvasive method of calculation of fractional flow reserve (FFR) using CCTA (FFR ) data has been developed. This noninvasive method yields similar results to invasive FFR measurement, improving specificity for noninvasively detecting lesion-specific ischemia thus helping guide revascularization.
冠状动脉计算机断层扫描血管造影（CCTA）已成为检测冠状动脉疾病（CAD）的一种既定的非侵入性方法。尽管CCTA对CAD检测具有较高的敏感性和阴性预测价值，但对阻塞性CAD的特异性相对较低，部分原因是冠状动脉钙化、成像伪影以及其他导致狭窄严重程度高估的因素。一种相对较新的利用CCTA（FFRCT）数据计算血流储备分数（FFR）的非侵入性方法已经开发出来。这种非侵入性方法产生的结果与侵入性FFR测量相似，提高了非侵入性检测病变特异性缺血的特异性，从而有助于指导血运重建。
