Gethin Georgina, O'Connor Gerard M, Abedin Jaynal, Newell John, Flynn Louisa, Watterson David, O'Loughlin Aorghus
Alliance for Research and Innovation in Wounds, NUI Galway, Galway, Ireland.
School of Nursing and Midwifery, NUI Galway, Galway, Ireland.
Wound Repair Regen. 2018 Mar;26(2):251-256. doi: 10.1111/wrr.12628. Epub 2018 May 19.
Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. To date, knowledge of their use has been predominantly in wound prevention, in vitro studies and single time measurements. Our objective was to determine surface pH, size, and surface temperature in noninfected, neuropathic foot ulcers at baseline and at 12 weeks. 50 patients (68% [n = 34] had diabetes) participated. Mean baseline pH of wounds was 6.95 (SD 1.01); temperature 30.91 °C (SD 3.00); and size 0.82 cm (SD 0.61). After 12 weeks, 26% (n = 13) were lost to follow-up, 50% (n = 25) had healed. Of the remaining patients, mean pH was 6.72 (SD 0.54); temperature 30.88 °C (SD 2.97), and size 0.13 cm (SD 0.13). We have provided baseline values for pH and temperature of noninfected, neuropathic diabetic, and nondiabetic foot ulceration. Further studies in a larger cohort are warranted to determine if temperature and or pH are indicative of a healing or nonhealing state.
伤口床评估很大程度上依赖主观判断，而没有借助客观工具或生物标志物。确定一种即时可用、可靠的生物标志物将有助于提高评估水平，并最终改善临床决策。目前有两种潜在的新兴伤口生物标志物：表面pH值和表面温度。迄今为止，关于它们的应用主要集中在伤口预防、体外研究和单次测量方面。我们的目标是确定未感染的神经性足部溃疡在基线期和12周时的表面pH值、大小和表面温度。50名患者（68%[n = 34]患有糖尿病）参与了研究。伤口的平均基线pH值为6.95（标准差1.01）；温度为30.91℃（标准差3.00）；大小为0.82平方厘米（标准差0.61）。12周后，26%（n = 13）的患者失访，50%（n = 25）的患者伤口愈合。在其余患者中，平均pH值为6.72（标准差0.54）；温度为30.88℃（标准差2.97），大小为0.13平方厘米（标准差0.13）。我们提供了未感染的神经性糖尿病和非糖尿病足部溃疡的pH值和温度的基线值。有必要在更大的队列中进行进一步研究，以确定温度和/或pH值是否能指示伤口愈合或未愈合状态。
