阿片类药物成瘾与血浆β-内啡肽样免疫反应性：美沙酮维持治疗、近期戒毒及早期接受纳曲酮治疗的戒毒者。

Opiate addiction and plasma beta-endorphin-like immunoreactivity: methadone maintained, recently detoxified and early naltrexone treated ex-addicts.

作者信息

Cushman P, Morris D, Adams M, Dewey W

出版信息

Alcohol Drug Res. 1987;7(5-6):533-40.

Abstract

Plasma beta-endorphin-like radioimmunoreactivity (BEND) was measured in opiate addicts and controls with an antisera which cross reacted with lipotropin but not with other endogenous opiate peptides. 43 stable male methadone maintained patients had mean BEND of 18 +/- 11 pg/ml. No relationship was found between BEND, and time of day, dose or time since last methadone. Controls had 22 +/- 8pg/ml. 9 hospitalized freshly detoxified male opiate addicts, 7-23 days after last opioid, had BEND of 32 +/- 11 pg/ml. These same took 7 days of 50 mg oral naltrexone (NTX) daily, and repeat BEND was 41 +/- 13 pg/ml, rising in all instances compared to baseline. Ex-addicts after detoxification had high BEND which rose further during a short course of NTX. Methadone maintained patients had normal BEND. These data are consistent with previous animal and human reports of high plasma BEND level with NTX or detoxification.

摘要

使用一种与促脂素发生交叉反应但不与其他内源性阿片肽发生交叉反应的抗血清，对阿片类药物成瘾者和对照组的血浆β-内啡肽样放射免疫活性（BEND）进行了测量。43名稳定的接受美沙酮维持治疗的男性患者的平均BEND为18±11 pg/ml。未发现BEND与一天中的时间、剂量或距上次服用美沙酮的时间之间存在关联。对照组的BEND为22±8 pg/ml。9名刚住院戒毒的男性阿片类药物成瘾者，在最后一次使用阿片类药物7 - 23天后，BEND为32±11 pg/ml。这些患者每日口服50毫克纳曲酮（NTX），持续7天，重复测量的BEND为41±13 pg/ml，与基线相比，所有患者的BEND均升高。戒毒后的戒断者BEND较高，在短期NTX治疗过程中进一步升高。接受美沙酮维持治疗的患者BEND正常。这些数据与之前关于NTX或戒毒后血浆BEND水平升高的动物和人体报告一致。