研究 d-柠檬烯纳米乳液对大肠杆菌 O157:H7 的抗群体感应活性。
Exploring the anti-quorum sensing activity of a d-limonene nanoemulsion for Escherichia coli O157:H7.
机构信息
College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.
Department of Agricultural and Biological Engineering, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana.
出版信息
J Biomed Mater Res A. 2018 Jul;106(7):1979-1986. doi: 10.1002/jbm.a.36404. Epub 2018 Apr 10.
In this study, a d-limonene nanoemulsion was developed by using a spontaneous emulsification method and its potential to inhibit the quorum sensing (QS)-regulated properties of Escherichia coli O157:H7 (E. coli) were revealed. The results in this study showed that d-limonene nanoemulsion inhibited E. coli biofilm formation through the suppression of curli and extracellular polymeric substance (EPS) production without inhibiting cell growth, and decreased swimming and swarming ability. Further analyses showed that d-limonene nanoemulsion interfered with auto-inducer 2 (AI-2) communication and repressed the expression of curli related genes and AI-2 importer genes in E. coli. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1979-1986, 2018.
在这项研究中，采用自发乳化法制备了柠檬烯纳米乳液，并揭示了其抑制大肠杆菌 O157:H7（E. coli）群体感应（QS）调节特性的潜力。本研究结果表明，柠檬烯纳米乳液通过抑制卷曲和细胞外聚合物（EPS）的产生而不抑制细胞生长来抑制大肠杆菌生物膜的形成，并降低了泳动和群集能力。进一步的分析表明，柠檬烯纳米乳液干扰了自诱导物 2（AI-2）的通讯，并抑制了大肠杆菌中卷曲相关基因和 AI-2 导入基因的表达。 © 2018 威利父子公司。J 生物医学材料研究部分 A：106A：1979-1986，2018。
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