For myosin light chain phosphatase, a very small subunit can make very big differences in the heart.
作者信息
Pearce William J
机构信息
Center for Perinatal Biology, Division of Physiology, Loma Linda University School of Medicine , Loma Linda, California.
出版信息
Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1157-H1159. doi: 10.1152/ajpheart.00164.2018. Epub 2018 Mar 23.
Abstract
摘要
相似文献
1
For myosin light chain phosphatase, a very small subunit can make very big differences in the heart.对于肌球蛋白轻链磷酸酶而言，一个非常小的亚基就能在心脏中产生非常大的差异。
Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1157-H1159. doi: 10.1152/ajpheart.00164.2018. Epub 2018 Mar 23.
2
Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.肌球蛋白轻链磷酸酶心脏特异性小亚基过表达导致心力衰竭和传导障碍。
Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1192-H1202. doi: 10.1152/ajpheart.00696.2017. Epub 2018 Feb 16.
3
Functional and Molecular Characterisation of Heart Failure Progression in Mice and the Role of Myosin Regulatory Light Chains in the Recovery of Cardiac Muscle Function.心力衰竭在小鼠中的功能和分子特征及肌球蛋白调节轻链在心肌功能恢复中的作用。
Int J Mol Sci. 2021 Dec 22;23(1):88. doi: 10.3390/ijms23010088.
4
M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.M-RIP将肌球蛋白磷酸酶靶向应力纤维，以调节血管平滑肌细胞中的肌球蛋白轻链磷酸化。
J Biol Chem. 2005 Dec 30;280(52):42543-51. doi: 10.1074/jbc.M506863200. Epub 2005 Oct 28.
5
Dephosphorylation of distinct sites on the 20 kDa myosin light chain by smooth muscle myosin phosphatase.平滑肌肌球蛋白磷酸酶对20 kDa肌球蛋白轻链上不同位点的去磷酸化作用。
FEBS Lett. 1999 Apr 1;448(1):101-4. doi: 10.1016/s0014-5793(99)00337-3.
6
Role of myosin light chain phosphatase in cardiac physiology and pathophysiology.肌球蛋白轻链磷酸酶在心脏生理和病理生理中的作用。
J Mol Cell Cardiol. 2016 Dec;101:35-43. doi: 10.1016/j.yjmcc.2016.10.004. Epub 2016 Oct 11.
7
Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle.回肠平滑肌中肌球蛋白磷酸酶靶向亚基-1磷酸化的生理信号传导
J Physiol. 2016 Jun 15;594(12):3209-25. doi: 10.1113/JP271703. Epub 2016 Mar 4.
8
Physiological vs. pharmacological signalling to myosin phosphorylation in airway smooth muscle.气道平滑肌肌球蛋白磷酸化的生理与药理学信号转导。
J Physiol. 2017 Oct 1;595(19):6231-6247. doi: 10.1113/JP274715. Epub 2017 Aug 24.
9
Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure.肌球蛋白磷酸酶靶向亚基1（MYPT1）调节血管平滑肌的收缩和舒张，并维持血压。
J Biol Chem. 2014 Aug 8;289(32):22512-23. doi: 10.1074/jbc.M113.525444. Epub 2014 Jun 20.
10
Decreased phosphatase activity, increased Ca2+ sensitivity, and myosin light chain phosphorylation in urinary bladder smooth muscle of newborn mice.新生小鼠膀胱平滑肌中磷酸酶活性降低、Ca2+敏感性增加以及肌球蛋白轻链磷酸化
J Gen Physiol. 2005 Feb;125(2):187-96. doi: 10.1085/jgp.200409212.
本文引用的文献
1
Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.肌球蛋白轻链磷酸酶心脏特异性小亚基过表达导致心力衰竭和传导障碍。
Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1192-H1202. doi: 10.1152/ajpheart.00696.2017. Epub 2018 Feb 16.
2
Vascular smooth muscle contraction in hypertension.高血压中的血管平滑肌收缩。
Cardiovasc Res. 2018 Mar 15;114(4):529-539. doi: 10.1093/cvr/cvy023.
3
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.平滑肌和非肌肉肌球蛋白II的钙离子敏感性：受G蛋白、激酶和肌球蛋白磷酸酶调节。
Physiol Rev. 2003 Oct;83(4):1325-58. doi: 10.1152/physrev.00023.2003.
4
Possibility of phosphorylation of myosin as the initial phase of the myosin-adenosinetri-phosphatase reaction.肌球蛋白磷酸化作为肌球蛋白-三磷酸腺苷酶反应初始阶段的可能性。
Biochim Biophys Acta. 1962 Feb 26;57:416-8. doi: 10.1016/0006-3002(62)91149-6.
5
Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit.
J Biol Chem. 2001 Mar 2;276(9):6073-82. doi: 10.1074/jbc.M008566200. Epub 2000 Nov 6.
6
A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.人肌球蛋白磷酸酶靶向/调节亚基（MYPT2）的一种新亚型：cDNA克隆、组织表达及染色体定位
Genomics. 1998 Apr 1;49(1):59-68. doi: 10.1006/geno.1998.5222.
7
The significance of phosphorylation of myosin light chains in heart.心肌中肌球蛋白轻链磷酸化的意义。
J Mol Cell Cardiol. 1984 Jul;16(7):591-5. doi: 10.1016/s0022-2828(84)80623-9.
8
9
Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes.蛋白磷酸酶抑制剂冈田酸对分离的豚鼠心肌细胞膜电流的影响。
Pflugers Arch. 1988 Aug;412(3):248-52. doi: 10.1007/BF00582504.
10
A calcium independent on-off switch for cardiac force generators.
Prog Clin Biol Res. 1989;315:473-9.
Zotero 插件