基于核苷的自组装药物用于局部药物递送。
Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery.
机构信息
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Advanced Drug Delivery, Pharmaceutical Sciences, IMED Biotech, AstraZeneca, Macclesfield, UK.
出版信息
ChemMedChem. 2018 Jun 6;13(11):1098-1101. doi: 10.1002/cmdc.201800063. Epub 2018 May 8.
We have synthesized a range of gelators based on the nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and transmission electron microscopy. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside-based gelators for localized drug delivery.
我们合成了一系列基于核苷类似物吉西他滨和拉米夫定的凝胶剂，使用流变学和透射电子显微镜对该系列中的代表性凝胶进行了表征。吉西他滨衍生物的生长抑制研究证实了这些化合物作为新型治疗方法的可行性，表明基于核苷的凝胶剂在局部药物输送方面具有潜力。
Zotero 插件