Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland.
Eur J Radiol. 2018 Apr;101:97-102. doi: 10.1016/j.ejrad.2018.02.020. Epub 2018 Feb 15.
To evaluate whether vessel-suppressed computed tomography (VSCT) can be reliably used for semi-automated volumetric measurements of solid pulmonary nodules, as compared to standard CT (SCT) MATERIAL AND METHODS: Ninety-three SCT were elaborated by dedicated software (ClearRead CT, Riverain Technologies, Miamisburg, OH, USA), that allows subtracting vessels from lung parenchyma. Semi-automated volumetric measurements of 65 solid nodules were compared between SCT and VSCT. The measurements were repeated by two readers. For each solid nodule, volume measured on SCT by Reader 1 and Reader 2 was averaged and the average volume between readers acted as standard of reference value. Concordance between measurements was assessed using Lin's Concordance Correlation Coefficient (CCC). Limits of agreement (LoA) between readers and CT datasets were evaluated.
Standard of reference nodule volume ranged from 13 to 366 mm. The mean overestimation between readers was 3 mm and 2.9 mm on SCT and VSCT, respectively. Semi-automated volumetric measurements on VSCT showed substantial agreement with the standard of reference (Lin's CCC = 0.990 for Reader 1; 0.985 for Reader 2). The upper and lower LoA between readers' measurements were (16.3, -22.4 mm) and (15.5, -21.4 mm) for SCT and VSCT, respectively.
VSCT datasets are feasible for the measurements of solid nodules, showing an almost perfect concordance between readers and with measurements on SCT.
评估血管抑制 CT（VSCT）是否可用于对实性肺结节进行半自动容积测量，与标准 CT（SCT）相比。
通过专用软件（美国俄亥俄州米米亚斯堡的 Riverain Technologies 的 ClearRead CT）对 93 例 SCT 进行了处理，该软件可从肺实质中减去血管。比较了 SCT 和 VSCT 对 65 个实性结节的半自动容积测量。由两名读者重复进行测量。对于每个实性结节，由读者 1 和读者 2 在 SCT 上测量的体积进行平均，读者之间的平均值作为参考值。使用林氏一致性相关系数（CCC）评估测量之间的一致性。评估了读者和 CT 数据集之间的界限（LoA）。
参考结节体积范围为 13 至 366mm。读者之间的平均高估分别为 SCT 和 VSCT 上的 3mm 和 2.9mm。VSCT 上的半自动容积测量与参考值具有高度一致性（读者 1 的 Lin's CCC=0.990；读者 2 的 Lin's CCC=0.985）。读者测量之间的上下 LoA 分别为 SCT（16.3，-22.4mm）和 VSCT（15.5，-21.4mm）。
VSCT 数据集可用于实性结节的测量，在读者之间以及与 SCT 上的测量具有几乎完美的一致性。
