Vytiska-Binstorfer E, Huber J C, Spona J, Gitsch E
Geburtshilfe Frauenheilkd. 1987 Jun;47(6):414-6. doi: 10.1055/s-2008-1036147.
"Post-pill amenorrhea" is still a much-debated subject in gynecological endocrinology. The authors therefore studied the reproductive history and endocrinological parameters of 145 patients with the presumptive diagnosis of post-pill amenorrhea, seen in their department during the last two years; 166 cases of secondary amenorrhea served as a control group. The incidence of late menarche (20%), previous oligomenorrhea, and elevated androgen serum levels was high in both groups. There were no significant differences between the two collectives. These findings suggest that although oral contraceptives may have an unfavorable influence on the menstrual cycle, there is no causal relationship between such agents and the development of secondary amenorrhea. It seems that in many cases of presumptive post-pill amenorrhea the common condition of juvenile hyperandrogenemic ovarian insufficiency might be the underlying problem.
“服药后闭经”仍是妇科内分泌学中一个备受争议的话题。因此，作者研究了过去两年在其科室就诊的145例疑似服药后闭经患者的生殖史和内分泌参数；166例继发性闭经患者作为对照组。两组初潮延迟（20%）、既往月经过少和血清雄激素水平升高的发生率均较高。两组之间无显著差异。这些发现表明，尽管口服避孕药可能对月经周期有不利影响，但此类药物与继发性闭经的发生之间没有因果关系。似乎在许多疑似服药后闭经的病例中，青少年高雄激素性卵巢功能不全这一常见情况可能是潜在问题。
