Chen Linyan, Fu Yiyun, Wang Haiyang, Yang Fuyao, Liu Jun, Xia Fan, Ma Xuelei
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, People's Republic of China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Head Neck. 2018 Jun;40(6):E62-E67. doi: 10.1002/hed.25150. Epub 2018 Mar 23.
Myoepithelial carcinoma is a rare salivary carcinoma, which most often arises from the major salivary glands. Only a few cases of myoepithelial carcinoma of the nasopharynx have been reported, thus, the treatment guideline and prognosis remain undefined.
We reported a case of nasopharyngeal myoepithelial carcinoma in a 31-year-old man. The tumor cells showed specific cell types and arrangements histologically, which were immunoreactive with myoepithelial markers. The patient received surgical excision with transpalatal approach. A literature review of previous cases was also presented.
The patient reflected residual tumor 4 weeks later. After concurrent chemoradiotherapy (CRT), the tumor reduced and remained stable without signs of progression.
The nasopharyngeal mass with spindled, plasmacytoid, epithelioid, and clear cell types, was suggested to raise the suspicion of myoepithelial carcinoma in order to diagnose and treat early. The wide surgical excision followed by optimal adjuvant therapy might offer a mode of treatment with better survival results.
肌上皮癌是一种罕见的涎腺癌，最常发生于大涎腺。仅有少数鼻咽部肌上皮癌的病例报道，因此，治疗指南和预后仍不明确。
我们报道了1例31岁男性鼻咽部肌上皮癌患者。肿瘤细胞在组织学上表现出特定的细胞类型和排列方式，对肌上皮标志物呈免疫反应。患者接受经腭入路手术切除。还对既往病例进行了文献回顾。
患者4周后出现肿瘤残留。同步放化疗后，肿瘤缩小并保持稳定，无进展迹象。
对于具有梭形、浆细胞样、上皮样和透明细胞类型的鼻咽部肿块，建议怀疑肌上皮癌以便早期诊断和治疗。广泛手术切除后辅以最佳辅助治疗可能提供一种具有更好生存结果的治疗方式。
