State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Virology. 2018 May;518:293-300. doi: 10.1016/j.virol.2018.02.003. Epub 2018 Mar 21.
MARCH2 is one of the MARCH family E3 ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 infection. MARCH2 inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention, a mechanism shared by MARCH8 that also leads to the inhibition of HIV-1 infection. Nevertheless, unlike MARCH8 and other MARCH proteins whose transcription levels are unrelated to viral infection, the expression level of MARCH2 is markedly upregulated upon HIV-1 infection, conferring MARCH2 a unique role in monitoring and regulating the HIV-1 infection-associated process.
MARCH2 是 MARCH 家族 E3 连接酶之一，包含十一个成员，在控制膜蛋白的周转率方面发挥着关键作用，如 MHC Ⅰ类、MHC Ⅱ类和细胞表面受体。在这项研究中，我们发现 HIV-1 感染会导致 MARCH2 的表达上调。MARCH2 通过连接酶活性依赖性包膜蛋白降解和/或细胞内滞留来抑制 HIV-1 的产生和感染，这一机制与 MARCH8 相同，也导致 HIV-1 感染的抑制。然而，与 MARCH8 和其他 MARCH 蛋白不同，MARCH8 和其他 MARCH 蛋白的转录水平与病毒感染无关，MARCH2 的表达水平在 HIV-1 感染时明显上调，赋予 MARCH2 在监测和调节 HIV-1 感染相关过程方面的独特作用。
Zotero 插件