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本文引用的文献

1
An Update on Adverse Outcome Pathways Leading to Liver Injury.导致肝损伤的不良结局途径的最新进展
Appl In Vitro Toxicol. 2017 Dec 1;3(4):283-285. doi: 10.1089/aivt.2017.0027. Epub 2017 Dec 6.
2
Adverse outcome pathways: opportunities, limitations and open questions.不良结局途径：机遇、局限性和未解决问题。
Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.
3
Adverse outcome pathways: a concise introduction for toxicologists.不良结局途径：毒理学家简明指南。
Arch Toxicol. 2017 Nov;91(11):3697-3707. doi: 10.1007/s00204-017-2020-z. Epub 2017 Jun 28.
4
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways.青霉素酶抗性抗生素通过 HSP27 激活诱导非免疫介导的胆汁淤积，该激活与 PKC/P38 和 PI3K/AKT 信号通路有关。
Sci Rep. 2017 May 12;7(1):1815. doi: 10.1038/s41598-017-01171-y.
5
The role of Kupffer cells in hepatic diseases.库普弗细胞在肝脏疾病中的作用。
Mol Immunol. 2017 May;85:222-229. doi: 10.1016/j.molimm.2017.02.018. Epub 2017 Mar 15.
6
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.胆汁酸通过触发肝细胞特异性炎症反应引发胆汁淤积性肝损伤。
JCI Insight. 2017 Mar 9;2(5):e90780. doi: 10.1172/jci.insight.90780.
7
Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes.评价转录组特征作为研究原代人肝细胞中药物性胆汁淤积的有价值工具。
Arch Toxicol. 2017 Aug;91(8):2879-2893. doi: 10.1007/s00204-017-1930-0. Epub 2017 Feb 10.
8
Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells.利用患者特异性诱导多能干细胞衍生的肝细胞样细胞生成胆汁盐输出泵缺陷模型。
Sci Rep. 2017 Feb 2;7:41806. doi: 10.1038/srep41806.
9
Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.作为药物性肝损伤预测性体外系统的干细胞衍生肝细胞、HepaRG细胞和三维人肝细胞球状体的转录、功能及机制比较
Drug Metab Dispos. 2017 Apr;45(4):419-429. doi: 10.1124/dmd.116.074369. Epub 2017 Jan 30.
10
Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.原代人肝细胞中的整合“组学”分析揭示了环孢素A诱导胆汁淤积的持续机制。
Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. doi: 10.1021/acs.chemrestox.6b00337. Epub 2016 Dec 2.

In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist.

作者信息

Vinken Mathieu

机构信息

Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.

出版信息

Arch Toxicol. 2018 May;92(5):1909-1912. doi: 10.1007/s00204-018-2201-4. Epub 2018 Mar 24.

DOI:10.1007/s00204-018-2201-4
PMID:29574564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6084771/
Abstract
摘要