University of Miami, 1500NW 12th Avenue, Suite 1101, Miami, FL 33136, USA.
Clin Liver Dis. 2013 Nov;17(4):519-31, vii. doi: 10.1016/j.cld.2013.07.015.
Drug-induced cholestasis manifests as an acute self-limiting injury or as a chronic perpetuating injury, resulting in duct loss and cirrhosis. The number of drugs implicated in drug-induced cholestasis grows every year as new drugs are developed and approved. Other agents such as herbals, nutritional supplements, and complementary and alternative medicines are also reported to cause cholestatic liver injury. Recent literature on molecular transporters involved in bile transport has improved our understanding of patterns of drug-induced liver injury and the mechanisms of cholestasis. This article summarizes the probable offending drugs, and the diagnosis and management of drug-induced cholestasis.
药物性胆汁淤积表现为急性自限性损伤或慢性持续性损伤，导致胆管损失和肝硬化。随着新药的开发和批准，每年涉及药物性胆汁淤积的药物数量都在增加。其他药物，如草药、营养补充剂和补充替代药物，也被报道可引起胆汁淤积性肝损伤。最近关于参与胆汁转运的分子转运体的文献提高了我们对药物性肝损伤模式和胆汁淤积机制的理解。本文总结了可能导致药物性胆汁淤积的药物，以及药物性胆汁淤积的诊断和治疗。
