Zoric Bojana, Jankovic Ljiljana, Kuzmanovic Pficer Jovana, Zidverc-Trajkovic Jasna, Mijajlovic Milija, Stanimirovic Dragan
Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Department for Medical Statistics and Informatics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Gerodontology. 2018 Jun;35(2):123-128. doi: 10.1111/ger.12332. Epub 2018 Mar 25.
Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS.
In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS).
Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P < .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P < .05).
Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.
灼口综合征（BMS）是一种口腔内的灼痛或感觉异常，在超过3个月的时间里每天反复出现超过两小时。目的是评估和分析5-羟色胺再摄取抑制剂氟西汀对灼口综合征患者心理因素以及疼痛的疗效。
在一项为期6个月的研究中，100名原发性和继发性灼口综合征患者被分为两组——氟西汀组和对照组（安慰剂组），并由牙医和神经科医生进行检查。采用汉密尔顿抑郁量表（HAM-D）、汉密尔顿焦虑量表（HAM-A）、贝克抑郁量表（BDI）评估抑郁和焦虑情况，采用视觉模拟量表（VAS）评估疼痛强度。
氟西汀组参与者的平均年龄为60.33岁，对照组为67.4岁。大多数参与者为女性——氟西汀组占74%，对照组占78%。氟西汀组和对照组在HAM-D结果上存在统计学差异（P < .05）。两组治疗后其他量表和VAS的值均显著下降（P < .05）。
我们的试验结果表明，氟西汀治疗不仅能改善灼口综合征患者的心理状态，还能降低这些患者的疼痛强度。
