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钌催化烯丙醇与游离吲哚的选择性碳-碳偶联：金属催化剂的影响

Ruthenium-Catalyzed Selective C-C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst.

作者信息

Xia Ying-Qi, Li Chao, Liu Man, Dong Lin

机构信息

Key laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, 610041, Chengdu, China.

出版信息

Chemistry. 2018 Apr 11;24(21):5474-5478. doi: 10.1002/chem.201706080. Epub 2018 Mar 25.

DOI:10.1002/chem.201706080
PMID:29575207
Abstract

Versatile reactive activities of allyl alcohols with free indoles in C-H functionalization reactions were investigated. Direct alkylation or cascade cyclization reactions could be selectively controlled based on the catalyst system: Ru(PPh ) Cl provided C3-substituted β-ketone indoles whereas [Ru(p-cymene)Cl ] yielded cyclized indoles.

摘要

研究了烯丙醇与游离吲哚在C-H官能化反应中的多种反应活性。基于催化剂体系，可以选择性地控制直接烷基化或级联环化反应：Ru(PPh ) Cl生成C3-取代的β-酮吲哚，而[Ru(p-异丙基苯)Cl ]生成环化吲哚。

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