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Long noncoding RNA MEG3, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis.长链非编码RNA MEG3，一种预测癌症患者临床结局的潜在新型生物标志物：一项荟萃分析。
Oncotarget. 2017 Mar 21;8(12):19049-19056. doi: 10.18632/oncotarget.14987.
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Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression.长链基因间非编码RNA 00152通过与EZH2相互作用并抑制IL24表达来促进肺腺癌增殖。
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4
Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets.长非编码 RNA 于癌症患者的潜力：从生物标志物到治疗靶点。
Int J Cancer. 2017 May 1;140(9):1955-1967. doi: 10.1002/ijc.30546. Epub 2016 Dec 30.
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MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1α and p53 pathways.MEG3、HCN3 和 linc01105 通过 HIF-1α 和 p53 通路影响神经母细胞瘤细胞的增殖和凋亡。
Sci Rep. 2016 Nov 8;6:36268. doi: 10.1038/srep36268.
6
Toward a Shared Vision for Cancer Genomic Data.迈向癌症基因组数据的共同愿景。
N Engl J Med. 2016 Sep 22;375(12):1109-12. doi: 10.1056/NEJMp1607591.
7
Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection.解析口腔癌lncRNA组：鉴定与恶性进展和人乳头瘤病毒感染相关的新型lncRNA
Oral Oncol. 2016 Aug;59:58-66. doi: 10.1016/j.oraloncology.2016.05.014.
8
The non-coding landscape of head and neck squamous cell carcinoma.头颈部鳞状细胞癌的非编码图谱
Oncotarget. 2016 Aug 9;7(32):51211-51222. doi: 10.18632/oncotarget.9979.
9
Upregulation of long noncoding RNA SPRY4-IT1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial-mesenchymal transition.长链非编码 RNA SPRY4-IT1 的上调通过诱导上皮-间充质转化促进食管鳞状细胞癌的转移。
Cell Biol Toxicol. 2016 Oct;32(5):391-401. doi: 10.1007/s10565-016-9341-1. Epub 2016 Jun 2.
10
From RNA isolation to microarray analysis: Comparison of methods in FFPE tissues.从RNA提取到微阵列分析：福尔马林固定石蜡包埋组织中方法的比较
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HPV 阴性头颈部鳞状细胞癌中长链非编码 RNA 的差异表达及其预后价值。

Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma.

机构信息

Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Head Neck. 2018 Jul;40(7):1555-1564. doi: 10.1002/hed.25136. Epub 2018 Mar 25.

DOI:10.1002/hed.25136
PMID:29575229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6037541/
Abstract

BACKGROUND

Long non-coding RNA (lncRNA) has emerged as a new avenue of interest due to its various biological functions in cancer. Abnormal expression of lncRNA has been reported in other malignancies but has been understudied in head and neck squamous cell carcinoma (HNSCC).

METHODS

The lncRNA expression was interrogated via quantitative real-time polymerase chain reaction (qRT-PCR) array for 19 human papillomavirus (HPV)-negative HNSCC tumor-normal pairs. The Cancer Genome Atlas (TCGA) was used to validate these results. The association between differentially expressed lncRNA and survival outcomes was analyzed.

RESULTS

Differential expression was validated for 5 lncRNA (SPRY4-IT1, HEIH, LUCAT1, LINC00152, and HAND2-AS1). There was also an inverse association between MEG3 expression (not significantly differentially expressed in TCGA tumors but highly variable expression) and 3-year recurrence-free survival (RFS).

CONCLUSION

We identified and validated differential expression of 5 lncRNA in HPV-negative HNSCC. Low MEG3 expression was associated with favorable 3-year RFS, although the significance of this finding remains unclear.

摘要

背景

长链非编码 RNA（lncRNA）因其在癌症中的各种生物学功能而成为一个新的研究热点。lncRNA 的异常表达已在其他恶性肿瘤中被报道，但在头颈部鳞状细胞癌（HNSCC）中研究较少。

方法

通过定量实时聚合酶链反应（qRT-PCR）阵列对 19 对 HPV 阴性 HNSCC 肿瘤-正常对进行 lncRNA 表达检测。使用癌症基因组图谱（TCGA）验证这些结果。分析差异表达 lncRNA 与生存结局的相关性。

结果

验证了 5 个 lncRNA（SPRY4-IT1、HEIH、LUCAT1、LINC00152 和 HAND2-AS1）的差异表达。MEG3 表达（在 TCGA 肿瘤中差异不显著，但表达高度可变）与 3 年无复发生存率（RFS）呈负相关。

结论

我们鉴定并验证了 HPV 阴性 HNSCC 中 5 个 lncRNA 的差异表达。低 MEG3 表达与 3 年 RFS 良好相关，尽管这一发现的意义尚不清楚。