Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, M5S3H6, Canada.
Chemistry. 2018 May 2;24(25):6543-6546. doi: 10.1002/chem.201801305. Epub 2018 Apr 17.
Catalytic hydrodefluorination (HDF) of unactivated fluoroalkanes or CF -substituted aryl species is performed using the P Lewis acids, [(bipy)PPh] (1 ) and [(terpy)PPh] (2 ) under mild conditions (25 or 50 °C). Mechanistic studies indicate that activation of C-F bond by the P center is key. Particularly noteworthy is that the catalyst 2[B(C F ) ] is air-stable and readily accessible from bench-stable, commercially available reagents in one-step and can be used without isolation.
使用 P 路易斯酸 [(bipy)PPh] (1) 和 [(terpy)PPh] (2) 在温和条件（25 或 50°C）下可实现未活化的全氟烷烃或 CF 取代的芳族物种的催化氢脱氟 (HDF)。机理研究表明，P 中心对 C-F 键的活化是关键。特别值得注意的是，催化剂 2[B(C F ) ] 是空气稳定的，并且可以一步从商业上可获得的、稳定的、 bench-stable 试剂中容易获得，并且可以在不进行分离的情况下使用。
