Divisions of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan.
Molecular Genetics, Institute of Life Science, Kurume University, Kurume 839-0864, Japan.
Cell Metab. 2018 Apr 3;27(4):786-804. doi: 10.1016/j.cmet.2018.02.008. Epub 2018 Mar 22.
Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting information about peripheral nutritional status to the brain, and is essential for protecting organisms against famine. Ghrelin operates brain circuits to regulate homeostatic and hedonic feeding. Recent research advances have shed new light on ghrelin's multifaceted roles in cellular homeostasis, which could maintain the internal environment and overcome metaflammation in metabolic organs. Here, we highlight our current understanding of the regulatory mechanisms of the ghrelin system in energy metabolism and cellular homeostasis and its clinical trials. Future studies of ghrelin will further elucidate how the stomach regulates systemic homeostasis.
胃饥饿素是一种胃来源的酰化肽，通过将外周营养状态的信息传递到大脑来调节能量稳态，对于保护生物免受饥饿至关重要。胃饥饿素作用于大脑回路以调节稳态和享乐性进食。最近的研究进展揭示了胃饥饿素在细胞稳态中的多方面作用，这有助于维持内环境并克服代谢器官的代谢炎症。在这里，我们重点介绍了我们对胃饥饿素系统在能量代谢和细胞稳态中的调节机制及其临床试验的理解。未来对胃饥饿素的研究将进一步阐明胃是如何调节全身稳态的。
