Department of Public Health, Hokkaido University Graduate School of Medicine.
Department of Pediatrics, Japan Ground Self Defense Forces Sapporo Hospital.
J Epidemiol. 2018 Aug 5;28(8):367-372. doi: 10.2188/jea.JE20170087. Epub 2018 Mar 24.
Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people.
We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses.
We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR], 1.67; 95% confidence interval [CI], 1.00-2.79 and HR, 2.10; 95% CI, 1.30-3.40). Further adjustment for possible confounders attenuated the association (HR, 1.63; 95% CI, 0.93-2.84 and HR, 2.10; 95% CI, 1.26-3.50). A similar but weaker association was seen for all-cause mortality (multivariate HR, 1.45; 95% CI, 0.95-2.21 and HR, 1.51; 95% CI, 1.01-2.25).
Plasma APN and cancer mortality have a significant relationship among community-dwelling elderly people, which warrants further study.
大多数关于社区居住的老年人血浆脂联素（APN）和死亡率的研究都集中在心血管疾病上，但关于血浆 APN 与癌症死亡率之间关系的数据很少。我们调查了 APN 是否与社区居住的老年人的癌症死亡率有关。
我们在新综合郊区老年人调查（NISSIN）项目中进行了病例-队列研究，使用 697 名受试者中的随机亚队列（351 名男性和 346 名女性；平均年龄 64.5[标准差，0.5]岁），在平均 10.8（标准差，3.7）年的随访期间，我们比较了全因死亡（n = 269）和癌症死亡（n = 149）的病例。使用加权 Cox 回归分析评估 APN 与死亡率之间的关系。
我们观察到，与第二 APN 三分位相比，APN 浓度与第一和第三 APN 三分位的癌症死亡呈显著正相关（危险比[HR]，1.67；95%置信区间[CI]，1.00-2.79 和 HR，2.10；95% CI，1.30-3.40）。进一步调整可能的混杂因素减弱了这种关联（HR，1.63；95% CI，0.93-2.84 和 HR，2.10；95% CI，1.26-3.50）。全因死亡率也存在类似但较弱的关联（多变量 HR，1.45；95% CI，0.95-2.21 和 HR，1.51；95% CI，1.01-2.25）。
社区居住的老年人血浆 APN 与癌症死亡率之间存在显著关系，值得进一步研究。
