采用彗星试验评估实验性子痫前期中的DNA损伤。

Evaluation of DNA Damage in Experimental Preeclampsia by Comet Assay.

作者信息

Kolesnikova S A, Eremina A I, Kustova M V, Muzyko E A, Dudchenko G P, Perfilova V N, Verovskii V Ye, Tyurenkov I N, Ostrovskii O V

机构信息

Department of Theoretical Biochemistry with Course of Clinical Biochemistry, Volgograd, Russia.

Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University of the Ministry of Health of Russian Federation, Volgograd, Russia.

出版信息

Bull Exp Biol Med. 2018 Mar;164(5):605-608. doi: 10.1007/s10517-018-4041-x. Epub 2018 Mar 26.

DOI:10.1007/s10517-018-4041-x

PMID:29577203

Abstract

Experimental preeclampsia induced by substitution of drinking water with 1.8% NaCl during pregnancy was associated with an increase in the level of DNA damage in fetal brain and placenta measured by DNA comet assay by 35.7 and 27.8 times, respectively, in comparison with physiological pregnancy.

摘要

孕期用1.8%氯化钠替代饮用水诱导的实验性先兆子痫，与生理妊娠相比，通过DNA彗星试验测得的胎儿脑和胎盘中DNA损伤水平分别增加了35.7倍和27.8倍。