Barngkgei Imad, Khattab Razan
Department of Oral Medicine, Faculty of Dentistry, Syrian Private University, Damascus, Syria.
Department of Oral Medicine, Faculty of Dentistry, Damascus University, Damascus, Syria.
J Investig Clin Dent. 2018 Aug;9(3):e12332. doi: 10.1111/jicd.12332. Epub 2018 Mar 25.
The aim of the present cross-sectional study was to investigate the effects of bisphosphonates (BP), prescribed for osteoporosis, on jawbones using multidetector computed tomography (MDCT).
Fifty-three women who had dual-energy X-ray absorptiometry examination were scanned by MDCT. Both the cortical and the trabecular parts of the alveolar and the cortical bones were compared between BP users and non-BP users using a number of radiological measurements. Linear regression was used for the statistical analysis.
The cortical part of the basal bone of the mandible revealed a significant increase in the BP group (.001 > P-value ≤ .026) after using BP for 5 years. No alternations were observed in the trabecular part of the basal bone or in the cortical or trabecular parts of the alveolar bone over the same duration.
The use of BP as a treatment for osteoporosis for 5 years increased the thickness of the cortex of the basal bone of the mandible, as detected by MDCT. The other parts of the jawbones showed no influence by BP for such a purpose, as detected on MDCT images. Accordingly, models (equations) for predicting the alternations in the inferior cortex of the mandible induced by BP therapy during osteoporosis have been suggested.
本横断面研究旨在使用多排螺旋计算机断层扫描（MDCT）研究用于治疗骨质疏松症的双膦酸盐（BP）对颌骨的影响。
对53名接受双能X线吸收测定检查的女性进行MDCT扫描。使用多种放射学测量方法，比较了BP使用者和非BP使用者牙槽骨和皮质骨的皮质和小梁部分。采用线性回归进行统计分析。
使用BP 5年后，BP组下颌骨基底骨的皮质部分有显著增加（0.001＞P值≤0.026）。在相同时间段内，基底骨小梁部分或牙槽骨皮质或小梁部分未观察到变化。
MDCT检测显示，使用BP治疗骨质疏松症5年增加了下颌骨基底骨皮质的厚度。MDCT图像显示，BP对颌骨的其他部分未产生此类影响。因此，提出了预测骨质疏松症期间BP治疗引起的下颌骨下缘皮质变化的模型（方程）。
